Components of the CtBP1/BARS-dependent fission machinery - PubMed (original) (raw)

Review

. 2013 Oct;140(4):407-21.

doi: 10.1007/s00418-013-1138-1. Epub 2013 Sep 1.

Affiliations

Review

Components of the CtBP1/BARS-dependent fission machinery

Carmen Valente et al. Histochem Cell Biol. 2013 Oct.

Abstract

The brefeldin A ADP-ribosylated substrate, a member of the C-terminal-binding protein family that is referred to as CtBP1/BARS, is a dual-function protein that acts as a transcriptional co-repressor in the nucleus and as an inducer of membrane fission in the cytoplasm. In this review, we first discuss the mechanisms that enable CtBP1/BARS to shift between the nuclear transcriptional co-repressor and the cytosolic fission-inducing activities. Then, we focus on the role of CtBP1/BARS in membrane fission. CtBP1/BARS controls several fission events including macropinocytosis, fluid-phase endocytosis, COPI-coated vesicle formation, basolaterally directed post-Golgi carrier formation, and Golgi partitioning in mitosis. We report on recent advances in our understanding of the CtBP1/BARS membrane fission machineries that operate at the trans-side and at the cis-side of the Golgi complex. Specifically, we discuss how these machineries are assembled and regulated, and how they operate in the formation of the basolaterally directed post-Golgi carriers.

PubMed Disclaimer

References

    1. Cell. 1998 Jul 24;94(2):151-4 -PubMed
    1. Biochim Biophys Acta. 2005 Jul 10;1744(3):455-64 -PubMed
    1. EMBO J. 2009 May 6;28(9):1197-207 -PubMed
    1. J Cell Biol. 2005 Apr 25;169(2):285-95 -PubMed
    1. Mol Biol Cell. 2003 Nov;14(11):4470-85 -PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources