Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology - PubMed (original) (raw)
Review
. 2013 Oct;19(10):604-13.
doi: 10.1016/j.molmed.2013.08.001. Epub 2013 Sep 2.
Affiliations
- PMID: 24007818
- DOI: 10.1016/j.molmed.2013.08.001
Review
Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology
Conor Mc Guire et al. Trends Mol Med. 2013 Oct.
Abstract
The nuclear factor kappa B (NF-κB) signaling cascade plays a critical role in the regulation of immune and inflammatory responses and has been implicated in the pathogenesis of autoimmune demyelinating diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the main animal model of MS. NF-κB is essential for peripheral immune cell activation and the induction of pathology, but also plays crucial roles in resident cells of the central nervous system (CNS) during disease development. Here we review recent evidence clarifying the role of NF-κB in the different cell compartments contributing to MS pathology and its implications for the development of therapeutic strategies for the treatment of MS and other demyelinating pathologies of the CNS.
Keywords: NF-κB; Th17; cuprizone; demyelination; experimental autoimmune encephalomyelitis; multiple sclerosis.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Similar articles
- Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice.
van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M, Lassmann H, Prinz MR, Pasparakis M. van Loo G, et al. Nat Immunol. 2006 Sep;7(9):954-61. doi: 10.1038/ni1372. Epub 2006 Aug 6. Nat Immunol. 2006. PMID: 16892069 - IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity.
Avloniti M, Evangelidou M, Gomini M, Loupis T, Emmanouil M, Mitropoulou A, Tselios T, Lassmann H, Gruart A, Delgado-García JM, Probert L, Kyrargyri V. Avloniti M, et al. J Neuroinflammation. 2024 Jan 27;21(1):34. doi: 10.1186/s12974-024-03023-9. J Neuroinflammation. 2024. PMID: 38279130 Free PMC article. - NF-κB Activation Accounts for the Cytoprotective Effects of PERK Activation on Oligodendrocytes during EAE.
Lei Z, Yue Y, Stone S, Wu S, Lin W. Lei Z, et al. J Neurosci. 2020 Aug 12;40(33):6444-6456. doi: 10.1523/JNEUROSCI.1156-20.2020. Epub 2020 Jul 13. J Neurosci. 2020. PMID: 32661025 Free PMC article. - Th17 cell, the new player of neuroinflammatory process in multiple sclerosis.
Jadidi-Niaragh F, Mirshafiey A. Jadidi-Niaragh F, et al. Scand J Immunol. 2011 Jul;74(1):1-13. doi: 10.1111/j.1365-3083.2011.02536.x. Scand J Immunol. 2011. PMID: 21338381 Review. - Th17 cells in central nervous system autoimmunity.
Sie C, Korn T, Mitsdoerffer M. Sie C, et al. Exp Neurol. 2014 Dec;262 Pt A:18-27. doi: 10.1016/j.expneurol.2014.03.009. Epub 2014 Mar 27. Exp Neurol. 2014. PMID: 24681001 Review.
Cited by
- Associations Between Neuroinflammation-Related Conditions and Alzheimer's Disease: A Study of US Insurance Claims Data.
Xu J, Chen Y, Shi Y, Sun A, Yang Y, Boustani M, Su J, Zhang P. Xu J, et al. J Alzheimers Dis. 2024;99(2):739-752. doi: 10.3233/JAD-231286. J Alzheimers Dis. 2024. PMID: 38701142 - Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies.
Magni G, Riboldi B, Ceruti S. Magni G, et al. Cells. 2024 Mar 30;13(7):606. doi: 10.3390/cells13070606. Cells. 2024. PMID: 38607045 Free PMC article. Review. - NF-κB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancer.
Lalle G, Lautraite R, Bouherrou K, Plaschka M, Pignata A, Voisin A, Twardowski J, Perrin-Niquet M, Stéphan P, Durget S, Tonon L, Ardin M, Degletagne C, Viari A, Belgarbi Dutron L, Davoust N, Postler TS, Zhao J, Caux C, Caramel J, Dalle S, Cassier PA, Klein U, Schmidt-Supprian M, Liblau R, Ghosh S, Grinberg-Bleyer Y. Lalle G, et al. J Exp Med. 2024 Jun 3;221(6):e20231348. doi: 10.1084/jem.20231348. Epub 2024 Apr 2. J Exp Med. 2024. PMID: 38563819 Free PMC article. - NF-κB in biology and targeted therapy: new insights and translational implications.
Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M, Zeng C, Zhou T, Zhang J. Guo Q, et al. Signal Transduct Target Ther. 2024 Mar 4;9(1):53. doi: 10.1038/s41392-024-01757-9. Signal Transduct Target Ther. 2024. PMID: 38433280 Free PMC article. Review. - Mechanisms Governing Oligodendrocyte Viability in Multiple Sclerosis and Its Animal Models.
Lei Z, Lin W. Lei Z, et al. Cells. 2024 Jan 9;13(2):116. doi: 10.3390/cells13020116. Cells. 2024. PMID: 38247808 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical