Direct determination of absolute molecular stereochemistry in gas phase by Coulomb explosion imaging - PubMed (original) (raw)

. 2013 Sep 6;341(6150):1096-100.

doi: 10.1126/science.1240362.

Maksim Kunitski, Allan S Johnson, Till Jahnke, Hendrik Sann, Felix Sturm, Lothar Ph H Schmidt, Horst Schmidt-Böcking, Reinhard Dörner, Jürgen Stohner, Julia Kiedrowski, Michael Reggelin, Sebastian Marquardt, Alexander Schießer, Robert Berger, Markus S Schöffler

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Direct determination of absolute molecular stereochemistry in gas phase by Coulomb explosion imaging

Martin Pitzer et al. Science. 2013.

Abstract

Bijvoet's method, which makes use of anomalous x-ray diffraction or dispersion, is the standard means of directly determining the absolute (stereochemical) configuration of molecules, but it requires crystalline samples and often proves challenging in structures exclusively comprising light atoms. Herein, we demonstrate a mass spectrometry approach that directly images the absolute configuration of individual molecules in the gas phase by cold target recoil ion momentum spectroscopy after laser ionization-induced Coulomb explosion. This technique is applied to the prototypical chiral molecule bromochlorofluoromethane and the isotopically chiral methane derivative bromodichloromethane.

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