Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults - PubMed (original) (raw)

Melissa M Markofski et al. J Gerontol A Biol Sci Med Sci. 2014 Jun.

Abstract

The purpose of this study was to observe exercise training-induced effects on adiponectin, leptin, and ghrelin. Twenty-nine older, healthy participants were classified as physically active (comparison group: N = 15, 70.9 ± 1.2 years) or physically inactive (exercise group: N = 14, 70.5 ± 1.4 years). Exercise group participants completed 12 weeks of combined aerobic and resistance exercise training, whereas comparison group participants maintained their current level of exercise and served as a physically active comparison group. Monocyte phenotype, as well as serum ghrelin, leptin, adiponectin, and soluble tumor necrosis factor receptor II were analyzed prior to and following the 12-week period. Ghrelin and adiponectin increased 47% and 55%, respectively, in exercise group participants following exercise training. Percent change in ghrelin (post and pre) was negatively correlated with the percent change in CD14+CD16+ monocytes (post and pre) in exercise group participants. Despite no changes in body mass, these data contribute to evidence for the anti-inflammatory effects of exercise.

Keywords: Adipokine; Anti-inflammatory.; Inflammation.

© The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figures

Figure 1.

Figure 1.

Ghrelin concentrations for the comparison (CON) and exercise (EX) groups at pre- and postexercise training. *Postexercise EX higher (p < .05) than baseline EX.

Figure 2.

Figure 2.

Leptin concentrations for the comparison (CON) and exercise (EX) groups at pre- and postexercise training. *Baseline EX higher (p < .05) than baseline CON (p < .05).

Figure 3.

Figure 3.

Adiponectin concentrations for the comparison (CON) and exercise (EX) groups at pre- and postexercise training. *Postexercise EX higher (p < .05) than baseline EX; †postexercise EX higher (p < .05) than baseline and postexercise CON.

Figure 4.

Figure 4.

Soluble tumor necrosis factor receptor II (sTNF-RII) for the comparison (CON) and exercise (EX) groups at pre- and postexercise training.

Figure 5.

Figure 5.

Correlation between adiponectin and body fat (A) and CD14+CD16+ percent change monocytes and ghrelin percent change (B).

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