Transient and locally restricted expression of laminin A chain mRNA by developing epithelial cells during kidney organogenesis - PubMed (original) (raw)
Transient and locally restricted expression of laminin A chain mRNA by developing epithelial cells during kidney organogenesis
M Ekblom et al. Cell. 1990.
Abstract
Three polypeptide chains, A, B1, and B2, have been described for mouse laminin, a basement membrane protein. We studied expression of laminin A, B1, and B2 mRNA in the developing mouse kidney. Induction of kidney mesenchyme differentiation in vitro led to an increased expression of B1 and B2 chain mRNA on day 1 of development. In contrast, expression of A chain mRNA increased on day 2, when epithelial cell polarization begins. Laminin A mRNA and polypeptide were expressed only by epithelia during in vivo development as well. Some polarized cell types producing basement membrane (endothelium, some adult epithelia) lacked the A chain mRNA and polypeptide, although they did express B chains. Laminin with the 400 kd A chain is therefore a transient form appearing at specific sites of kidney morphogenesis, whereas isoforms with a different A chain or without it have a more widespread distribution.
Similar articles
- Differential expression of five laminin alpha (1-5) chains in developing and adult mouse kidney.
Sorokin LM, Pausch F, Durbeej M, Ekblom P. Sorokin LM, et al. Dev Dyn. 1997 Dec;210(4):446-62. doi: 10.1002/(SICI)1097-0177(199712)210:4<446::AID-AJA8>3.0.CO;2-G. Dev Dyn. 1997. PMID: 9415429 - The expression of the genes for entactin, laminin A, laminin B1 and laminin B2 in murine lens morphogenesis and eye development.
Dong LJ, Chung AE. Dong LJ, et al. Differentiation. 1991 Dec;48(3):157-72. doi: 10.1111/j.1432-0436.1991.tb00254.x. Differentiation. 1991. PMID: 1725162 - Non-muscle alpha-dystroglycan is involved in epithelial development.
Durbeej M, Larsson E, Ibraghimov-Beskrovnaya O, Roberds SL, Campbell KP, Ekblom P. Durbeej M, et al. J Cell Biol. 1995 Jul;130(1):79-91. doi: 10.1083/jcb.130.1.79. J Cell Biol. 1995. PMID: 7790379 Free PMC article. - Developmentally regulated conversion of mesenchyme to epithelium.
Ekblom P. Ekblom P. FASEB J. 1989 Aug;3(10):2141-50. doi: 10.1096/fasebj.3.10.2666230. FASEB J. 1989. PMID: 2666230 Review. - Laminin isoforms and epithelial development.
Ekblom M, Falk M, Salmivirta K, Durbeej M, Ekblom P. Ekblom M, et al. Ann N Y Acad Sci. 1998 Oct 23;857:194-211. doi: 10.1111/j.1749-6632.1998.tb10117.x. Ann N Y Acad Sci. 1998. PMID: 9917842 Review.
Cited by
- Laminin: loss-of-function studies.
Yao Y. Yao Y. Cell Mol Life Sci. 2017 Mar;74(6):1095-1115. doi: 10.1007/s00018-016-2381-0. Epub 2016 Oct 1. Cell Mol Life Sci. 2017. PMID: 27696112 Free PMC article. Review. - Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues.
Clay MR, Sherwood DR. Clay MR, et al. Curr Top Membr. 2015;76:337-71. doi: 10.1016/bs.ctm.2015.08.001. Epub 2015 Sep 12. Curr Top Membr. 2015. PMID: 26610919 Free PMC article. Review. - Stem Cell-Soluble Signals Enhance Multilumen Formation in SMG Cell Clusters.
Maruyama CL, Leigh NJ, Nelson JW, McCall AD, Mellas RE, Lei P, Andreadis ST, Baker OJ. Maruyama CL, et al. J Dent Res. 2015 Nov;94(11):1610-7. doi: 10.1177/0022034515600157. Epub 2015 Aug 18. J Dent Res. 2015. PMID: 26285810 Free PMC article. - Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210.
Olsson M, English MA, Mason J, Licht JD, Ekblom P. Olsson M, et al. J Negat Results Biomed. 2004 Dec 21;3:7. doi: 10.1186/1477-5751-3-7. J Negat Results Biomed. 2004. PMID: 15613247 Free PMC article. - The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M. Munesue S, et al. Biochem J. 2002 Apr 15;363(Pt 2):201-9. doi: 10.1042/0264-6021:3630201. Biochem J. 2002. PMID: 11931647 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical