Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins - PubMed (original) (raw)

Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins

J M Caron. Mol Cell Biol. 1990 Mar.

Abstract

Transcriptional activity of the albumin gene was induced in primary cultures of hepatocytes by adding dilute concentrations of basement membrane-like proteins derived from the EHS mouse sarcoma tumor to established type I collagen cultures. By immunofluorescence microscopy with antialbumin antibody, the population of cells responded uniformly to dilute EHS. Of the three major components of EHS, purified laminin was as effective as unfractionated EHS at inducing an increase in albumin mRNA levels and albumin secretion; type IV collagen and heparan sulfate proteoglycan were ineffective.

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References

1. 1. Cold Spring Harb Symp Quant Biol. 1983;48 Pt 2:611-23 - PubMed
2. 1. J Biol Chem. 1983 Jul 25;258(14):8922-7 - PubMed
3. 1. J Biol Chem. 1984 Jun 25;259(12):7416-20 - PubMed
4. 1. J Cell Biol. 1985 Oct;101(4):1511-22 - PubMed
5. 1. EMBO J. 1985 Oct;4(10):2487-91 - PubMed

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