Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA - PubMed (original) (raw)
. 2013 Sep 26;155(1):94-106.
doi: 10.1016/j.cell.2013.08.029.
Affiliations
- PMID: 24074863
- DOI: 10.1016/j.cell.2013.08.029
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Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA
Salomé Adam et al. Cell. 2013.
Free article
Abstract
Understanding how to recover fully functional and transcriptionally active chromatin when its integrity has been challenged by genotoxic stress is a critical issue. Here, by investigating how chromatin dynamics regulate transcriptional activity in response to DNA damage in human cells, we identify a pathway involving the histone chaperone histone regulator A (HIRA) to promote transcription restart after UVC damage. Our mechanistic studies reveal that HIRA accumulates at sites of UVC irradiation upon detection of DNA damage prior to repair and deposits newly synthesized H3.3 histones. This local action of HIRA depends on ubiquitylation events associated with damage recognition. Furthermore, we demonstrate that the early and transient function of HIRA in response to DNA damage primes chromatin for later reactivation of transcription. We propose that HIRA-dependent histone deposition serves as a chromatin bookmarking system to facilitate transcription recovery after genotoxic stress.
Copyright © 2013 Elsevier Inc. All rights reserved.
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