The changing role of beta-blocker therapy in patients with cirrhosis - PubMed (original) (raw)
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doi: 10.1016/j.jhep.2013.09.016. Epub 2013 Sep 26.
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- PMID: 24076364
- DOI: 10.1016/j.jhep.2013.09.016
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Review
The changing role of beta-blocker therapy in patients with cirrhosis
Phillip S Ge et al. J Hepatol. 2014 Mar.
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Abstract
Cirrhosis is a leading cause of death in the United States and worldwide. Beta-blockers have been established in numerous studies as part of the cornerstone of the medical management of cirrhosis, particularly in the primary and secondary prevention of variceal hemorrhage. However, new evidence has cautioned the use of beta-blockers in patients with end-stage cirrhosis and refractory ascites. In this article, we review the beneficial effects of beta-blocker therapy, the potential harms of aggressive beta-blocker therapy, and provide suggestions regarding the appropriate use of this class of medications in patients with cirrhosis.
Keywords: Ascites; Beta blockers; Cirrhosis; Portal hypertension; Variceal hemorrhage.
Copyright © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Comment in
- An apology for beta blockers.
Thalheimer U, Bosch J, Burroughs AK. Thalheimer U, et al. J Hepatol. 2014 Aug;61(2):450-1. doi: 10.1016/j.jhep.2014.03.040. Epub 2014 Apr 24. J Hepatol. 2014. PMID: 24768757 No abstract available. - Beta-blockers in cirrhosis: therapeutic window or an aspirin for all?
Ferrarese A, Tsochatzis E, Burroughs AK, Senzolo M. Ferrarese A, et al. J Hepatol. 2014 Aug;61(2):449-50. doi: 10.1016/j.jhep.2014.03.038. Epub 2014 Apr 24. J Hepatol. 2014. PMID: 24768827 No abstract available. - Beta-blockers in cirrhosis: thank you for your attention.
Ge PS, Runyon BA. Ge PS, et al. J Hepatol. 2014 Aug;61(2):451-2. doi: 10.1016/j.jhep.2014.04.024. Epub 2014 May 2. J Hepatol. 2014. PMID: 24792969 No abstract available.
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