Neural tube defects, folate, and immune modulation - PubMed (original) (raw)
Review
Neural tube defects, folate, and immune modulation
Kerina J Denny et al. Birth Defects Res A Clin Mol Teratol. 2013 Sep.
Abstract
Periconceptional supplementation with folic acid has led to a significant worldwide reduction in the incidence of neural tube defects (NTDs). However, despite increasing awareness of the benefits of folic acid supplementation and the implementation of food fortification programs in many countries, NTDs continue to be a leading cause of perinatal morbidity and mortality worldwide. Furthermore, there exists a significant subgroup of women who appear to be resistant to the protective effects of folic acid supplementation. The following review addresses emerging clinical and experimental evidence for a role of the immune system in the etiopathogenesis of NTDs, with the aim of developing novel preventative strategies to further reduce the incidence of NTD-affected pregnancies. In particular, recent studies demonstrating novel roles and interactions between innate immune factors such as the complement cascade, neurulation, and folate metabolism are explored.
Keywords: C5a; complement; folate; neural tube defects; neurulation.
Copyright © 2013 Wiley Periodicals, Inc.
Figures
Figure 1
The connecting links between neural tube defects (NTDs), immune factors, and folate. Many lines of evidence now link two of the three hubs, while recent evidence shows that knockout or inhibition of the innate immune complement receptor, C5aR, leads to neural tube defects under conditions of folate deficiency (Denny et al., 2013). Notes contained in blue boxes relate to positive relationships, notes in red boxes relate to inverse or negative relationships. 1Denny et al. (2013). 2 Girardi et al. (2008). 3Lomaga et al. (2000); McGrath et al. (1999); McLin et al. (2008); Phelan et al. (2005); Regnier et al. (2002); Tissir et al. (2004). 4Torchinsky et al. (1997); Hrubec et al. (2006). 5Greene et al. (2009b). 6Spiegelstein et al. (2004). 7Smithells et al. (1976). 8Duthie et al. (2010). 9Cabrera et al. (2008). 10Hammons et al. (2009). [Color figure can be viewed in the online issue, which is available at
wileyonlinelibrary.com
.]
Similar articles
- Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression.
Beaudin AE, Stover PJ. Beaudin AE, et al. Birth Defects Res C Embryo Today. 2007 Sep;81(3):183-203. doi: 10.1002/bdrc.20100. Birth Defects Res C Embryo Today. 2007. PMID: 17963270 Review. - Neural tube defects: pathogenesis and folate metabolism.
Pulikkunnel ST, Thomas SV. Pulikkunnel ST, et al. J Assoc Physicians India. 2005 Feb;53:127-35. J Assoc Physicians India. 2005. PMID: 15847033 Review. - Folate and neural tube defects. Recommendations from a Danish working group.
Rasmussen LB, Andersen NL, Andersson G, Lange AP, Rasmussen K, Skak-Iversen L, Skovby F, Ovesen L. Rasmussen LB, et al. Dan Med Bull. 1998 Apr;45(2):213-7. Dan Med Bull. 1998. PMID: 9587705 Review. - Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
Candito M, Naimi M, Boisson C, Rudigoz JC, Gaucherand P, Guéant JL, Luton D, Van Obberghen E. Candito M, et al. Birth Defects Res A Clin Mol Teratol. 2007 Jan;79(1):62-4. doi: 10.1002/bdra.20318. Birth Defects Res A Clin Mol Teratol. 2007. PMID: 17120234 - Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
Yerby MS. Yerby MS. Neurology. 2003 Sep 1;61(6 Suppl 2):S23-6. doi: 10.1212/wnl.61.6_suppl_2.s23. Neurology. 2003. PMID: 14504306 Review.
Cited by
- Determinants of neural tube defects among newborns in public referral hospitals in Eastern Ethiopia.
Mohamed FA, Dheresa M, Raru TB, Yusuf N, Hassen TA, Mehadi A, Wilfong T, Tukeni KN, Kure MA, Roba KT. Mohamed FA, et al. BMC Nutr. 2023 Jul 25;9(1):93. doi: 10.1186/s40795-023-00752-7. BMC Nutr. 2023. PMID: 37491389 Free PMC article. - Identification of immune-related biomarkers in embryos with neural tube defects via a bioinformatics analysis.
Huang Q, Yang L, Nong B, Gan H, Wu H, Li M, Jin M, Xie L. Huang Q, et al. Ann Transl Med. 2022 May;10(9):521. doi: 10.21037/atm-22-1273. Ann Transl Med. 2022. PMID: 35928755 Free PMC article. - Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake.
Eszlari N, Bruncsics B, Millinghoffer A, Hullam G, Petschner P, Gonda X, Breen G, Antal P, Bagdy G, Deakin JFW, Juhasz G. Eszlari N, et al. Nutrients. 2021 Dec 8;13(12):4396. doi: 10.3390/nu13124396. Nutrients. 2021. PMID: 34959947 Free PMC article. - Systems biology analysis of human genomes points to key pathways conferring spina bifida risk.
Aguiar-Pulido V, Wolujewicz P, Martinez-Fundichely A, Elhaik E, Thareja G, Abdel Aleem A, Chalhoub N, Cuykendall T, Al-Zamer J, Lei Y, El-Bashir H, Musser JM, Al-Kaabi A, Shaw GM, Khurana E, Suhre K, Mason CE, Elemento O, Finnell RH, Ross ME. Aguiar-Pulido V, et al. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2106844118. doi: 10.1073/pnas.2106844118. Proc Natl Acad Sci U S A. 2021. PMID: 34916285 Free PMC article. - Maternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring.
Hoang TT, Lei Y, Mitchell LE, Sharma SV, Swartz MD, Waller DK, Finnell RH, Benjamin RH, Browne ML, Canfield MA, Lupo PJ, McKenzie P, Shaw GM, Agopian AJ; National Birth Defects Prevention Study. Hoang TT, et al. Mol Genet Genomic Med. 2019 Jun;7(6):e688. doi: 10.1002/mgg3.688. Epub 2019 Apr 9. Mol Genet Genomic Med. 2019. PMID: 30968606 Free PMC article.
References
- Attilakos A, Papakonstantinou E, Schulpis K, et al. Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy. Epilepsy Res. 2006;71:229–232. - PubMed
- Benard M, Raoult E, Vaudry D, et al. Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum. Mol Immunol. 2008;45:3767–3774. - PubMed
- Botto LD, Moore CA, Khoury MJ, Erickson JD. Neural-tube defects. N Engl J Med. 1999;341:1509–1519. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- R01 ES021006/ES/NIEHS NIH HHS/United States
- NS076465/NS/NINDS NIH HHS/United States
- HD067244/HD/NICHD NIH HHS/United States
- R01 NS076465/NS/NINDS NIH HHS/United States
- R21 HD072251/HD/NICHD NIH HHS/United States
- P01 HD067244/HD/NICHD NIH HHS/United States
- ES021390/ES/NIEHS NIH HHS/United States
- HD072251/HD/NICHD NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical