Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46 - PubMed (original) (raw)

. 1990 Mar 2;247(4946):1077-9.

doi: 10.1126/science.2408148.

Affiliations

• PMID: 2408148
• DOI: 10.1126/science.2408148

Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46

A B Sachs et al. Science. 1990.

Abstract

Cold-sensitive mutations in the SPB genes (spb1-spb7) of Saccharomyces cerevisiae suppress the inhibition of translation initiation resulting from deletion of the poly(A)-binding protein gene (PAB1). The SPB4 protein belongs to a family of adenosine triphosphate (ATP)-dependent RNA helicases. The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits the deletion of PAB1. These data suggest that mutations affecting different steps of 60S subunit formation can allow PAB-independent translation, and they indicate that further characterization of the spb mutations could lend insight into the biogenesis of the ribosome.

PubMed Disclaimer

Similar articles

• The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation.
  Sachs AB, Davis RW. Sachs AB, et al. Cell. 1989 Sep 8;58(5):857-67. doi: 10.1016/0092-8674(89)90938-0. Cell. 1989. PMID: 2673535
• Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-rRNA processing predominantly at site A3.
  Weaver PL, Sun C, Chang TH. Weaver PL, et al. Mol Cell Biol. 1997 Mar;17(3):1354-65. doi: 10.1128/MCB.17.3.1354. Mol Cell Biol. 1997. PMID: 9032262 Free PMC article.
• Dbp7p, a putative ATP-dependent RNA helicase from Saccharomyces cerevisiae, is required for 60S ribosomal subunit assembly.
  Daugeron MC, Linder P. Daugeron MC, et al. RNA. 1998 May;4(5):566-81. doi: 10.1017/s1355838298980190. RNA. 1998. PMID: 9582098 Free PMC article.
• Saccharomyces cerevisiae, a Powerful Model for Studying rRNA Modifications and Their Effects on Translation Fidelity.
  Baudin-Baillieu A, Namy O. Baudin-Baillieu A, et al. Int J Mol Sci. 2021 Jul 10;22(14):7419. doi: 10.3390/ijms22147419. Int J Mol Sci. 2021. PMID: 34299038 Free PMC article. Review.
• Nuclear export and cytoplasmic maturation of ribosomal subunits.
  Zemp I, Kutay U. Zemp I, et al. FEBS Lett. 2007 Jun 19;581(15):2783-93. doi: 10.1016/j.febslet.2007.05.013. Epub 2007 May 11. FEBS Lett. 2007. PMID: 17509569 Review.

Cited by

• Global mRNA selection mechanisms for translation initiation.
  Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PF, Grant CM, Pavitt GD, Hubbard SJ, Ashe MP. Costello J, et al. Genome Biol. 2015 Jan 5;16(1):10. doi: 10.1186/s13059-014-0559-z. Genome Biol. 2015. PMID: 25650959 Free PMC article.
• deaD, a new Escherichia coli gene encoding a presumed ATP-dependent RNA helicase, can suppress a mutation in rpsB, the gene encoding ribosomal protein S2.
  Toone WM, Rudd KE, Friesen JD. Toone WM, et al. J Bacteriol. 1991 Jun;173(11):3291-302. doi: 10.1128/jb.173.11.3291-3302.1991. J Bacteriol. 1991. PMID: 2045359 Free PMC article.
• Power of yeast for analysis of eukaryotic translation initiation.
  Altmann M, Linder P. Altmann M, et al. J Biol Chem. 2010 Oct 15;285(42):31907-12. doi: 10.1074/jbc.R110.144196. Epub 2010 Aug 6. J Biol Chem. 2010. PMID: 20693283 Free PMC article. Review. No abstract available.
• Autoregulation of expression of the yeast Dbp2p 'DEAD-box' protein is mediated by sequences in the conserved DBP2 intron.
  Barta I, Iggo R. Barta I, et al. EMBO J. 1995 Aug 1;14(15):3800-8. doi: 10.1002/j.1460-2075.1995.tb00049.x. EMBO J. 1995. PMID: 7641698 Free PMC article.
• Mutations in STS1 suppress the defect in 3' mRNA processing caused by the rna15-2 mutation in Saccharomyces cerevisiae.
  Amrani N, Dufour ME, Bonneaud N, Lacroute F. Amrani N, et al. Mol Gen Genet. 1996 Oct 16;252(5):552-62. doi: 10.1007/BF02172401. Mol Gen Genet. 1996. PMID: 8914516

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • Saccharomyces Genome Database