To B or not to B--that is the question for myocardial infarction - PubMed (original) (raw)

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. 2013 Oct;19(10):1208-10.

doi: 10.1038/nm.3367.

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• PMID: 24100978
• DOI: 10.1038/nm.3367

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To B or not to B--that is the question for myocardial infarction

Nancy D Kim et al. Nat Med. 2013 Oct.

Abstract

After myocardial infarction (MI), circulating B cells produce the chemokine Ccl7, which mobilizes inflammatory monocytes from the bone marrow into the blood, after which they are then recruited to the injured heart, a new study shows. B cell depletion after MI limits myocardial injury and improves heart function, suggesting a new approach for the management of acute MI (pages 1273–1280).

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• B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.
  Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin C, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti S, Bruneval P, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, Silvestre JS, Mallat Z. Zouggari Y, et al. Nat Med. 2013 Oct;19(10):1273-80. doi: 10.1038/nm.3284. Epub 2013 Sep 15. Nat Med. 2013. PMID: 24037091 Free PMC article.

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