The non-coding skin: exploring the roles of long non-coding RNAs in epidermal homeostasis and disease - PubMed (original) (raw)
Review
. 2013 Dec;35(12):1093-100.
doi: 10.1002/bies.201300068. Epub 2013 Sep 25.
Affiliations
- PMID: 24115003
- DOI: 10.1002/bies.201300068
Review
The non-coding skin: exploring the roles of long non-coding RNAs in epidermal homeostasis and disease
Sonja Hombach et al. Bioessays. 2013 Dec.
Abstract
Long non-coding RNAs (lncRNAs) have recently gained increasing attention because of their crucial roles in gene regulatory processes. Functional studies using mammalian skin as a model system have revealed their role in controlling normal tissue homeostasis as well as the transition to a diseased state. Here, we describe how lncRNAs regulate differentiation to preserve an undifferentiated epidermal progenitor compartment, and to maintain a functional skin permeability barrier. Furthermore, we will reflect on recent work analyzing the impact of lncRNAs on the progression from normal epithelium to the development of skin disorders and cancer.
Keywords: differentiation; epidermis; lncRNA; melanoma; non-coding RNA; skin.
© 2013 WILEY Periodicals, Inc.
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