The receptor-destroying enzyme of influenza C virus is neuraminate-O-acetylesterase - PubMed (original) (raw)

The receptor-destroying enzyme of influenza C virus is neuraminate-O-acetylesterase

G Herrler et al. EMBO J. 1985 Jun.

Abstract

The nature of the receptor-destroying enzyme (RDE) of influenza C virus has been elucidated by analyzing its effect on the haemagglutination inhibitors rat alpha 1-macroglobulin (RMG) and bovine submandibulary mucin (BSM), respectively. The inhibitory activity of both compounds is abolished by incubation with influenza C virus. After inactivation, RMG and BSM were found to contain reduced amounts of N-acetyl-9-O-acetylneuraminic acid (Neu5,9Ac2) and increased amounts of N-acetylneuraminic acid (Neu5Ac). H.p.l.c. analysis revealed that purified Neu5,9Ac2 is converted to Neu5Ac by incubation with influenza C virus. These results demonstrate that RDE of influenza C virus is neuraminate-O-acetylesterase [N-acyl-9(4)-O-acetylneuraminate O-acetylhydrolase (EC 3.1.1.53)]. The data also indicate that haemagglutination-inhibition (HI) by RMG and BSM and most likely virus attachment to cell surfaces involves binding of influenza C virus to Neu5,9Ac2.

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References

1. 1. Virology. 1975 May;65(1):87-99 - PubMed
2. 1. Eur J Biochem. 1974 Dec 16;50(1):71-82 - PubMed
3. 1. Methods Enzymol. 1978;50:64-89 - PubMed
4. 1. Microbiol Immunol. 1978;22(4):197-203 - PubMed
5. 1. Virology. 1979 Nov;99(1):49-56 - PubMed

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