Spontaneous muscarinic suppression of the Ca-activated K-current in bullfrog sympathetic neurons - PubMed (original) (raw)
Comparative Study
Spontaneous muscarinic suppression of the Ca-activated K-current in bullfrog sympathetic neurons
T Tokimasa. Brain Res. 1985.
Abstract
Neurons in bullfrog sympathetic ganglia were voltage-clamped using a single microelectrode. A prolonged outward current which was identified as the Ca-activated K-current secondary to a transient Ca entry through voltage-operated channels was shortened by oxotremorine. An inward Ca-current was not significantly depressed by oxotremorine. It was suggested that muscarinic agonists accelerate the re-closure of K-channels either directly or secondarily via their effects on an intracellular sequestration process of Ca ions. It was also suggested that a small amount of acetylcholine only sufficient to cause a miniature synaptic current via nicotinic receptors could shorten the Ca-activated K-current via muscarinic receptors.
Similar articles
- Muscarinic agonists depress calcium-dependent gK in bullfrog sympathetic neurons.
Tokimasa T. Tokimasa T. J Auton Nerv Syst. 1984 Apr;10(2):107-16. doi: 10.1016/0165-1838(84)90049-3. J Auton Nerv Syst. 1984. PMID: 6086736 - Intracellular Ca2+-ions inactivate K+-current in bullfrog sympathetic neurons.
Tokimasa T. Tokimasa T. Brain Res. 1985 Jul 1;337(2):386-91. doi: 10.1016/0006-8993(85)90081-2. Brain Res. 1985. PMID: 2411338 - Calcium entry through acetylcholine-channels can activate potassium conductance in bullfrog sympathetic neurons.
Tokimasa T, North RA. Tokimasa T, et al. Brain Res. 1984 Mar 19;295(2):364-7. doi: 10.1016/0006-8993(84)90987-9. Brain Res. 1984. PMID: 6324950 - Voltage-dependent currents of vertebrate neurons and their role in membrane excitability.
Adams PR, Galvan M. Adams PR, et al. Adv Neurol. 1986;44:137-70. Adv Neurol. 1986. PMID: 2422889 Review. - Regulation of the M current: transduction mechanism and role in ganglionic transmission.
Smith PA, Chen H, Kurenny DE, Selyanko AA, Zidichouski JA. Smith PA, et al. Can J Physiol Pharmacol. 1992;70 Suppl:S12-8. doi: 10.1139/y92-238. Can J Physiol Pharmacol. 1992. PMID: 1338293 Review.
Cited by
- Pharmacological and physiological properties of the after-hyperpolarization current of bullfrog ganglion neurones.
Goh JW, Pennefather PS. Goh JW, et al. J Physiol. 1987 Dec;394:315-30. doi: 10.1113/jphysiol.1987.sp016872. J Physiol. 1987. PMID: 2451018 Free PMC article. - Intrinsic properties of neurones in the dorsal cochlear nucleus of mice, in vitro.
Hirsch JA, Oertel D. Hirsch JA, et al. J Physiol. 1988 Feb;396:535-48. doi: 10.1113/jphysiol.1988.sp016976. J Physiol. 1988. PMID: 2457693 Free PMC article. - The effects of soman on the electrical properties and excitability of bullfrog sympathetic ganglion neurones.
Heppner TJ, Fiekers JF. Heppner TJ, et al. Br J Pharmacol. 1991 Aug;103(4):1985-91. doi: 10.1111/j.1476-5381.1991.tb12364.x. Br J Pharmacol. 1991. PMID: 1912986 Free PMC article. - Muscarinic agonists and potassium currents in guinea-pig myenteric neurones.
Galligan JJ, North RA, Tokimasa T. Galligan JJ, et al. Br J Pharmacol. 1989 Jan;96(1):193-203. doi: 10.1111/j.1476-5381.1989.tb11800.x. Br J Pharmacol. 1989. PMID: 2924071 Free PMC article. - Autoregulation of acetylcholine release from vagus nerve terminals through activation of muscarinic receptors in the dog trachea.
Ito Y, Yoshitomi T. Ito Y, et al. Br J Pharmacol. 1988 Mar;93(3):636-46. doi: 10.1111/j.1476-5381.1988.tb10321.x. Br J Pharmacol. 1988. PMID: 3370392 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical