Lack of association of IDH1, IDH2 and DNMT3A mutations with outcome in older patients with acute myeloid leukemia treated with hypomethylating agents - PubMed (original) (raw)
doi: 10.3109/10428194.2013.855309. Epub 2014 Feb 4.
Keyur P Patel, Guillermo Garcia-Manero, Rajyalakshmi Luthra, Sherry Pierce, Gautam Borthakur, Elias Jabbour, Tapan Kadia, Naveen Pemmaraju, Marina Konopleva, Stefan Faderl, Jorge Cortes, Hagop M Kantarjian, Farhad Ravandi
Affiliations
- PMID: 24138309
- PMCID: PMC4139917
- DOI: 10.3109/10428194.2013.855309
Lack of association of IDH1, IDH2 and DNMT3A mutations with outcome in older patients with acute myeloid leukemia treated with hypomethylating agents
Courtney D DiNardo et al. Leuk Lymphoma. 2014 Aug.
No abstract available
Conflict of interest statement
Conflict of Interest Disclosure: The authors declare no competing financial interest
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References
- Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrozek K, Margeson D, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2010;28(14):2348–55. Epub 2010/04/07. - PMC - PubMed
- Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A, et al. Mutation in TET2 in myeloid cancers. The New England journal of medicine. 2009;360(22):2289–301. Epub 2009/05/29. - PubMed
- Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nature genetics. 2010;42(8):722–6. Epub 2010/07/06. - PubMed
- Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa R, 3rd, Patel Y, Harden A, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proceedings of the National Academy of Sciences of the United States of America. 1991;88(23):10735–9. Epub 1991/12/11. - PMC - PubMed
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