An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula - PubMed (original) (raw)
Review
. 2013 Dec;4(12):1767-75.
doi: 10.1039/c3fo60298b. Epub 2013 Oct 22.
Affiliations
- PMID: 24150114
- DOI: 10.1039/c3fo60298b
Review
An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula
Emily K K Tai et al. Food Funct. 2013 Dec.
Abstract
Human milk is the ideal food providing optimal nutrition for healthy term infants. Its complex lipid composition is critical for infant growth and serves as a golden standard for baby formula development. Docosahexaenoic acid (C22:6 n- 3, DHA) and arachidonic acid (C20:4 n- 6, AA) are the two major long chain polyunsaturated fatty acids (PUFAs) in human milk. In humans, they are fundamental components of the cell membrane and play an important role in neurite growth and signal transmission. Their importance for both preterm and term infants has been demonstrated by various clinical trials. DHA and AA supplementation shows desirable influences on visual and cognitive development in early life and is additionally associated with potential benefits on later health. Further clinical data revealed that supplementing both DHA and AA instead of DHA alone during infancy is important to deliver the optimal outcome. In this review, we summarize current research and scientific evidence of DHA and AA on baby development.
Similar articles
- Should formula for infants provide arachidonic acid along with DHA? A position paper of the European Academy of Paediatrics and the Child Health Foundation.
Koletzko B, Bergmann K, Brenna JT, Calder PC, Campoy C, Clandinin MT, Colombo J, Daly M, Decsi T, Demmelmair H, Domellöf M, FidlerMis N, Gonzalez-Casanova I, van Goudoever JB, Hadjipanayis A, Hernell O, Lapillonne A, Mader S, Martin CR, Matthäus V, Ramakrishan U, Smuts CM, Strain SJJ, Tanjung C, Tounian P, Carlson SE. Koletzko B, et al. Am J Clin Nutr. 2020 Jan 1;111(1):10-16. doi: 10.1093/ajcn/nqz252. Am J Clin Nutr. 2020. PMID: 31665201 - The European Food Safety Authority recommendation for polyunsaturated fatty acid composition of infant formula overrules breast milk, puts infants at risk, and should be revised.
Crawford MA, Wang Y, Forsyth S, Brenna JT. Crawford MA, et al. Prostaglandins Leukot Essent Fatty Acids. 2015 Dec;102-103:1-3. doi: 10.1016/j.plefa.2015.07.005. Epub 2015 Sep 21. Prostaglandins Leukot Essent Fatty Acids. 2015. PMID: 26432509 - Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials.
Hoffman DR, Boettcher JA, Diersen-Schade DA. Hoffman DR, et al. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):151-8. doi: 10.1016/j.plefa.2009.05.003. Epub 2009 Jun 7. Prostaglandins Leukot Essent Fatty Acids. 2009. PMID: 19505812 Review. - Evidence for the essentiality of arachidonic and docosahexaenoic acid in the postnatal maternal and infant diet for the development of the infant's immune system early in life.
Richard C, Lewis ED, Field CJ. Richard C, et al. Appl Physiol Nutr Metab. 2016 May;41(5):461-75. doi: 10.1139/apnm-2015-0660. Epub 2016 Jan 22. Appl Physiol Nutr Metab. 2016. PMID: 27138971 Review. - Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids.
Hoffman DR, Wheaton DK, James KJ, Tuazon M, Diersen-Schade DA, Harris CL, Stolz S, Berseth CL. Hoffman DR, et al. J Pediatr Gastroenterol Nutr. 2006 Mar;42(3):287-92. doi: 10.1097/01.mpg.0000189366.91792.64. J Pediatr Gastroenterol Nutr. 2006. PMID: 16540798 Clinical Trial.
Cited by
- Comparison Among Commonly Available Infant Formula Milks in the Iraqi Market.
Mikhael EM. Mikhael EM. Glob Pediatr Health. 2015 Oct 6;2:2333794X15608716. doi: 10.1177/2333794X15608716. eCollection 2015. Glob Pediatr Health. 2015. PMID: 27335982 Free PMC article. - Modification of erythrocyte membrane phospholipid composition in preterm newborns with retinopathy of prematurity: The omegaROP study.
Karadayi R, Pallot C, Cabaret S, Mazzocco J, Gabrielle PH, Semama DS, Chantegret C, Ternoy N, Martin D, Donier A, Gregoire S, Creuzot-Garcher CP, Bron AM, Bretillon L, Berdeaux O, Acar N. Karadayi R, et al. Front Cell Dev Biol. 2022 Sep 9;10:921691. doi: 10.3389/fcell.2022.921691. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36158214 Free PMC article. - Human Milk Macronutrients and Child Growth and Body Composition in the First Two Years: A Systematic Review.
Brockway MM, Daniel AI, Reyes SM, Granger M, McDermid JM, Chan D, Refvik R, Sidhu KK, Musse S, Patel PP, Monnin C, Lotoski L, Geddes D, Jehan F, Kolsteren P, Allen LH, Hampel D, Eriksen KG, Rodriguez N, Azad MB. Brockway MM, et al. Adv Nutr. 2024 Jan;15(1):100149. doi: 10.1016/j.advnut.2023.100149. Epub 2023 Nov 18. Adv Nutr. 2024. PMID: 37981047 Free PMC article. - Docosahexaenoic acid-rich algae oil supplementation on breast milk fatty acid profile of mothers who delivered prematurely: a randomized clinical trial.
Fougère H, Bilodeau JF, Lavoie PM, Mohamed I, Rudkowska I, Pronovost E, Simonyan D, Berthiaume L, Guillot M, Piedboeuf B, Julien P, Marc I. Fougère H, et al. Sci Rep. 2021 Nov 2;11(1):21492. doi: 10.1038/s41598-021-01017-8. Sci Rep. 2021. PMID: 34728723 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical