Impact of TRPV3 on the development of allergic dermatitis as a dendritic cell modulator - PubMed (original) (raw)
Impact of TRPV3 on the development of allergic dermatitis as a dendritic cell modulator
Erika Yamamoto-Kasai et al. Exp Dermatol. 2013 Dec.
Abstract
The transient receptor potential channel vanilloid subfamily V member 3 (TRPV3), which functions as a thermosensor in keratinocytes, plays an important role in the development of allergic and itchy dermatitis in rodents. Although real-time PCR analysis using lesional and non-lesional skin samples from patients with atopic dermatitis showed that TRPV3 was expressed in lesional skin, the role that TRPV3 plays in patients with dermatitis is still relatively obscure. Here, we determined whether TRPV3 was a dendritic cell (DC) modulator using DS-Nh mice with a gain-of-function mutation in TRPV3 (TRPV3Gly573Ser), because increasing skin temperature is associated with the modulation of dermal dendritic cells (DCs). Interestingly, increased responses to haptens by skin and DCs were observed in DS-Nh mice compared with those from DS mice with wild-type TRPV3. Increased thymic stromal lymphopoietin (TSLP) responses were also observed in keratinocytes from DS-Nh mice compared with those from DS mice. Taken together, we propose that the DS-Nh mouse is a good model to use in order to better understand the role of this orphan channel and that TRPV3 may represent a new therapeutic target in certain types of dermatitis through the control of DCs.
Keywords: atopic dermatitis; contact hypersensitivity; dendritic cell; thymic stromal lymphopoietin; transient receptor potential vanilloid subfamily V member 3.
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
- Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice.
Yoshioka T, Imura K, Asakawa M, Suzuki M, Oshima I, Hirasawa T, Sakata T, Horikawa T, Arimura A. Yoshioka T, et al. J Invest Dermatol. 2009 Mar;129(3):714-22. doi: 10.1038/jid.2008.245. Epub 2008 Aug 28. J Invest Dermatol. 2009. PMID: 18754035 - Enhanced Thermal Sensitivity of TRPV3 in Keratinocytes Underlies Heat-Induced Pruritogen Release and Pruritus in Atopic Dermatitis.
Seo SH, Kim S, Kim SE, Chung S, Lee SE. Seo SH, et al. J Invest Dermatol. 2020 Nov;140(11):2199-2209.e6. doi: 10.1016/j.jid.2020.02.028. Epub 2020 Apr 2. J Invest Dermatol. 2020. PMID: 32247859 - TSLP acts on infiltrating effector T cells to drive allergic skin inflammation.
He R, Oyoshi MK, Garibyan L, Kumar L, Ziegler SF, Geha RS. He R, et al. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11875-80. doi: 10.1073/pnas.0801532105. Epub 2008 Aug 18. Proc Natl Acad Sci U S A. 2008. PMID: 18711124 Free PMC article. - Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation.
Liu YJ. Liu YJ. J Allergy Clin Immunol. 2007 Aug;120(2):238-44; quiz 245-6. doi: 10.1016/j.jaci.2007.06.004. J Allergy Clin Immunol. 2007. PMID: 17666213 Review. - Thymic stromal lymphopoietin: a promising therapeutic target for allergic diseases.
Wang WL, Li HY, Zhang MS, Gao PS, He SH, Zheng T, Zhu Z, Zhou LF. Wang WL, et al. Int Arch Allergy Immunol. 2013;160(1):18-26. doi: 10.1159/000341665. Epub 2012 Aug 30. Int Arch Allergy Immunol. 2013. PMID: 22948028 Review.
Cited by
- TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways.
Wang Y, Li H, Xue C, Chen H, Xue Y, Zhao F, Zhu MX, Cao Z. Wang Y, et al. Cell Biol Toxicol. 2021 Apr;37(2):313-330. doi: 10.1007/s10565-020-09536-2. Epub 2020 Jun 13. Cell Biol Toxicol. 2021. PMID: 32535744 - Skin Barrier and Calcium.
Lee SE, Lee SH. Lee SE, et al. Ann Dermatol. 2018 Jun;30(3):265-275. doi: 10.5021/ad.2018.30.3.265. Epub 2018 Apr 23. Ann Dermatol. 2018. PMID: 29853739 Free PMC article. Review. - Genetic Signature of Acute Lymphoblastic Leukemia and Netherton Syndrome Co-incidence-First Report in the Literature.
Skoczen S, Stepien K, Mlynarski W, Centkowski P, Kwiecinska K, Korostynski M, Piechota M, Wyrobek E, Moryl-Bujakowska A, Strojny W, Rej M, Kowalczyk J, Balwierz W. Skoczen S, et al. Front Oncol. 2020 Jan 17;9:1477. doi: 10.3389/fonc.2019.01477. eCollection 2019. Front Oncol. 2020. PMID: 32010610 Free PMC article. - Transient receptor potential vanilloid 3 expression is increased in non-lesional skin of atopic dermatitis patients.
Vasas N, Pénzes Z, Kistamás K, Nánási PP, Molnár S, Szegedi A, Szöllősi AG, Bíró T. Vasas N, et al. Exp Dermatol. 2022 May;31(5):807-813. doi: 10.1111/exd.14530. Epub 2022 Feb 4. Exp Dermatol. 2022. PMID: 35038353 Free PMC article. - TRPV3: Structure, Diseases and Modulators.
Su W, Qiao X, Wang W, He S, Liang K, Hong X. Su W, et al. Molecules. 2023 Jan 12;28(2):774. doi: 10.3390/molecules28020774. Molecules. 2023. PMID: 36677834 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources