Kinase C activator 1,2-oleoylacetylglycerol attenuates voltage-dependent calcium current in sensory neurons - PubMed (original) (raw)

Kinase C activator 1,2-oleoylacetylglycerol attenuates voltage-dependent calcium current in sensory neurons

S G Rane et al. Proc Natl Acad Sci U S A. 1986 Jan.

Abstract

The diacylglycerol analogue 1,2-oleoylacetylglycerol (OAG) and the phorbol ester 12-deoxyphorbol 13-isobutyrate (DPB) were tested for their effects on the voltage-dependent calcium (Ca) current in embryonic chicken dorsal root ganglion neurons in vitro. OAG (0.6-60 microM) and DPB (0.01-50 microM) produced reversible decreases in Ca current. Neither drug affected resting membrane conductance, the voltage-dependent potassium current, or the Ca current-voltage relationship. The concentrations of OAG and DPB that reduced Ca current correlate well with those concentrations that have been shown, in other systems, to activate protein kinase C-dependent phosphorylation. The time course for OAG action on Ca current is also consistent with an involvement of kinase C. Incubation of dorsal root ganglion cells in 60 microM OAG prevented further reductions in Ca current by either 50 microM DPB or 10 microM norepinephrine, a known modulator of the voltage-dependent Ca channel in these cells. This evidence suggests that protein kinase C may play a role in modulating Ca channel function.

PubMed Disclaimer

Similar articles

• The protein kinase C activator 1-oleoyl-2-acetylglycerol inhibits voltage-dependent Ca2+ current in the pituitary cell line AtT-20.
  Lewis DL, Weight FF. Lewis DL, et al. Neuroendocrinology. 1988 Feb;47(2):169-75. doi: 10.1159/000124909. Neuroendocrinology. 1988. PMID: 2449624
• Protein kinase activator 1-oleoyl-2-acetyl-sn-glycerol inhibits two types of calcium currents in GH3 cells.
  Marchetti C, Brown AM. Marchetti C, et al. Am J Physiol. 1988 Jan;254(1 Pt 1):C206-10. doi: 10.1152/ajpcell.1988.254.1.C206. Am J Physiol. 1988. PMID: 2447796
• A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation.
  Hockberger P, Toselli M, Swandulla D, Lux HD. Hockberger P, et al. Nature. 1989 Mar 23;338(6213):340-2. doi: 10.1038/338340a0. Nature. 1989. PMID: 2922062
• Dual actions of phorbol esters to decrease calcium and potassium conductances of mouse neurons.
  Werz MA, Macdonald RL. Werz MA, et al. Neurosci Lett. 1987 Jul 9;78(1):101-6. doi: 10.1016/0304-3940(87)90569-6. Neurosci Lett. 1987. PMID: 2441331

Cited by

• ATP regulates muscarine-sensitive potassium current in dissociated bull-frog primary afferent neurones.
  Tokimasa T, Akasu T. Tokimasa T, et al. J Physiol. 1990 Jul;426:241-64. doi: 10.1113/jphysiol.1990.sp018136. J Physiol. 1990. PMID: 2121960 Free PMC article.
• Rapid aquaporin translocation regulates cellular water flow: mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel.
  Conner MT, Conner AC, Bland CE, Taylor LH, Brown JE, Parri HR, Bill RM. Conner MT, et al. J Biol Chem. 2012 Mar 30;287(14):11516-25. doi: 10.1074/jbc.M111.329219. Epub 2012 Feb 9. J Biol Chem. 2012. PMID: 22334691 Free PMC article.
• Parathyroid hormone enhances calcium current in snail neurones--simulation of the effect by phorbol esters.
  Kostyuk PG, Lukyanetz EA, Ter-Markosyan AS. Kostyuk PG, et al. Pflugers Arch. 1992 Feb;420(2):146-52. doi: 10.1007/BF00374983. Pflugers Arch. 1992. PMID: 1320249
• Antibodies to an alpha subunit of skeletal muscle calcium channels regulate parathyroid cell secretion.
  Fitzpatrick LA, Chin H, Nirenberg M, Aurbach GD. Fitzpatrick LA, et al. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2115-9. doi: 10.1073/pnas.85.7.2115. Proc Natl Acad Sci U S A. 1988. PMID: 2451241 Free PMC article.
• Properties of calcium channels in cardiac muscle and vascular smooth muscle.
  Sperelakis N. Sperelakis N. Mol Cell Biochem. 1990 Dec 20;99(2):97-109. doi: 10.1007/BF00230339. Mol Cell Biochem. 1990. PMID: 1962848 Review.

References

1. 1. Nat New Biol. 1972 Dec 6;240(101):181-3 - PubMed
2. 1. Nature. 1977 Sep 22;269(5626):342-4 - PubMed
3. 1. Biochem Biophys Res Commun. 1979 Dec 28;91(4):1218-24 - PubMed
4. 1. J Biol Chem. 1980 Mar 25;255(6):2273-6 - PubMed
5. 1. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7039-43 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central