A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review) - PubMed (original) (raw)

A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review)

Yun-Long Fan et al. Oncol Lett. 2013 Nov.

Abstract

Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions, increasing evidence suggests that CSCs are involved in VM formation. Recent studies have indicated that EMT is relevant to the acquisition and maintenance of stem cell-like characteristics. Thus, in this review we discuss the correlation between CSCs, EMT and VM formation.

Keywords: angiogenesis; cancer stem cell; epithelial-mesenchymal transition; metastasis; vasculogenic mimicry.

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Figures

Figure 1

Figure 1

Schematic diagram representing the VM formation involved in CSCs and EMT. VM, vasculogenic mimicry; CSC, cancer stem cell; EMT, epithelial-mesenchymal transition.

References

    1. Hillen F, Griffioen AW. Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev. 2007;26:489–502. - PMC - PubMed
    1. Maniotis AJ, Folberg R, Hess A, et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol. 1999;155:739–752. - PMC - PubMed
    1. El Hallani S, Boisselier B, Peglion F, et al. A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry. Brain. 2010;133:973–982. - PMC - PubMed
    1. van der Schaft DW, Hillen F, Pauwels P, et al. Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res. 2005;65:11520–11528. - PubMed
    1. Shirakawa K, Kobayashi H, Heike Y, et al. Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft. Cancer Res. 2002;62:560–566. - PubMed

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