Creatine supplementation and aging musculoskeletal health - PubMed (original) (raw)

Review

Creatine supplementation and aging musculoskeletal health

Darren G Candow et al. Endocrine. 2014 Apr.

Abstract

Sarcopenia refers to the progressive loss of muscle mass and muscle function and is a contributing factor for cachexia, bone loss, and frailty. Resistance training produces several physiological adaptations which improve aging musculoskeletal health, such as increased muscle and bone mass and strength. The combination of creatine supplementation and resistance training may further lead to greater physiological benefits. We performed meta-analyses which indicate creatine supplementation combined with resistance training has a positive effect on aging muscle mass and upper body strength compared to resistance training alone. Creatine also shows promise for improving bone mineral density and indices of bone biology. The combination of creatine supplementation and resistance training could be an effective intervention to improve aging musculoskeletal health.

PubMed Disclaimer

Similar articles

• Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia.
  Candow DG, Chilibeck PD, Forbes SC, Fairman CM, Gualano B, Roschel H. Candow DG, et al. Bone. 2022 Sep;162:116467. doi: 10.1016/j.bone.2022.116467. Epub 2022 Jun 7. Bone. 2022. PMID: 35688360 Review.
• Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults.
  Candow DG, Forbes SC, Kirk B, Duque G. Candow DG, et al. Nutrients. 2021 Feb 26;13(3):745. doi: 10.3390/nu13030745. Nutrients. 2021. PMID: 33652673 Free PMC article. Review.
• Sarcopenia: current theories and the potential beneficial effect of creatine application strategies.
  Candow DG. Candow DG. Biogerontology. 2011 Aug;12(4):273-81. doi: 10.1007/s10522-011-9327-6. Epub 2011 Mar 4. Biogerontology. 2011. PMID: 21373890 Review.
• Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial.
  Gualano B, Macedo AR, Alves CR, Roschel H, Benatti FB, Takayama L, de Sá Pinto AL, Lima FR, Pereira RM. Gualano B, et al. Exp Gerontol. 2014 May;53:7-15. doi: 10.1016/j.exger.2014.02.003. Epub 2014 Feb 13. Exp Gerontol. 2014. PMID: 24530883 Clinical Trial.
• The Additive Effects of Creatine Supplementation and Exercise Training in an Aging Population: A Systematic Review of Randomized Controlled Trials.
  Stares A, Bains M. Stares A, et al. J Geriatr Phys Ther. 2020 Apr/Jun;43(2):99-112. doi: 10.1519/JPT.0000000000000222. J Geriatr Phys Ther. 2020. PMID: 30762623

Cited by

• Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults?
  Candow DG, Moriarty T. Candow DG, et al. Curr Osteoporos Rep. 2024 Nov 1;23(1):1. doi: 10.1007/s11914-024-00895-x. Curr Osteoporos Rep. 2024. PMID: 39509039 Review.
• Fueling the Firefighter and Tactical Athlete with Creatine: A Narrative Review of a Key Nutrient for Public Safety.
  Gonzalez DE, Forbes SC, Zapp A, Jagim A, Luedke J, Dickerson BL, Root A, Gil A, Johnson SE, Coles M, Brager A, Sowinski RJ, Candow DG, Kreider RB. Gonzalez DE, et al. Nutrients. 2024 Sep 28;16(19):3285. doi: 10.3390/nu16193285. Nutrients. 2024. PMID: 39408252 Free PMC article. Review.
• Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis.
  Pashayee-Khamene F, Heidari Z, Asbaghi O, Ashtary-Larky D, Goudarzi K, Forbes SC, Candow DG, Bagheri R, Ghanavati M, Dutheil F. Pashayee-Khamene F, et al. J Int Soc Sports Nutr. 2024 Dec;21(1):2380058. doi: 10.1080/15502783.2024.2380058. Epub 2024 Jul 23. J Int Soc Sports Nutr. 2024. PMID: 39042054 Free PMC article. Review.
• Effect of different reheating processes and conditions on the nutritional, functional, and microbiological properties of cow meat.
  Nanje OS, Sylvia Ninying VZ, Tonfack Djikeng F, Azia Morfor T, Achidi AU. Nanje OS, et al. Food Sci Nutr. 2024 Mar 18;12(6):4233-4247. doi: 10.1002/fsn3.4083. eCollection 2024 Jun. Food Sci Nutr. 2024. PMID: 38873459 Free PMC article.
• Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care-clinically relevant 3PM innovation.
  Golubnitschaja O, Kapinova A, Sargheini N, Bojkova B, Kapalla M, Heinrich L, Gkika E, Kubatka P. Golubnitschaja O, et al. EPMA J. 2024 Apr 18;15(2):163-205. doi: 10.1007/s13167-024-00358-4. eCollection 2024 Jun. EPMA J. 2024. PMID: 38841620 Free PMC article.

References

1. 1. J Int Soc Sports Nutr. 2007 Aug 30;4:6 - PubMed
2. 1. Mech Ageing Dev. 2003 Mar;124(3):287-99 - PubMed
3. 1. J Nutr Health Aging. 2008 Mar;12(3):208-12 - PubMed
4. 1. J Appl Physiol (1985). 1993 Aug;75(2):813-9 - PubMed
5. 1. Int J Sport Nutr Exerc Metab. 2000 Sep;10(3):235-44 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations

• Medical

  • MedlinePlus Health Information