Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins - PubMed (original) (raw)
Comparative Study
. 1986 Apr 1;136(7):2348-57.
- PMID: 2419430
Comparative Study
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
T R Mosmann et al. J Immunol. 1986.
Abstract
A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished. Type 1 T helper cells (TH1) produced IL 2, interferon-gamma, GM-CSF, and IL 3 in response to antigen + presenting cells or to Con A, whereas type 2 helper T cells (TH2) produced IL 3, BSF1, and two other activities unique to the TH2 subset, a mast cell growth factor distinct from IL 3 and a T cell growth factor distinct from IL 2. Clones representing each type of T cell were characterized, and the pattern of lymphokine activities was consistent within each set. The secreted proteins induced by Con A were analyzed by biosynthetic labeling and SDS gel electrophoresis, and significant differences were seen between the two groups of T cell line. Both types of T cell grew in response to alternating cycles of antigen stimulation, followed by growth in IL 2-containing medium. Examples of both types of T cell were also specific for or restricted by the I region of the MHC, and the surface marker phenotype of the majority of both types was Ly-1+, Lyt-2-, L3T4+, Both types of helper T cell could provide help for B cells, but the nature of the help differed. TH1 cells were found among examples of T cell clones specific for chicken RBC and mouse alloantigens. TH2 cells were found among clones specific for mouse alloantigens, fowl gamma-globulin, and KLH. The relationship between these two types of T cells and previously described subsets of T helper cells is discussed.
Similar articles
- Patterns of lymphokine production by primary antigen-specific/MHC restricted murine helper T cell clones.
Hatfield SM, Rodgers GH, Marder P, Roehm NW. Hatfield SM, et al. Immunol Invest. 1991 Feb;20(1):55-73. doi: 10.3109/08820139109054925. Immunol Invest. 1991. PMID: 1711510 - Heterogeneity in lymphokine profiles of CD4+ and CD8+ T cells and clones activated in vivo and in vitro.
Kelso A, Troutt AB, Maraskovsky E, Gough NM, Morris L, Pech MH, Thomson JA. Kelso A, et al. Immunol Rev. 1991 Oct;123:85-114. doi: 10.1111/j.1600-065x.1991.tb00607.x. Immunol Rev. 1991. PMID: 1684785 Review. - Regulation of T-cell activation: differences among T-cell subsets.
Gajewski TF, Schell SR, Nau G, Fitch FW. Gajewski TF, et al. Immunol Rev. 1989 Oct;111:79-110. doi: 10.1111/j.1600-065x.1989.tb00543.x. Immunol Rev. 1989. PMID: 2534116 Review.
Cited by
- Inflammation-associated genes: risks and benefits to Foxp3+ regulatory T-cell function.
O'Connor RA, Anderton SM. O'Connor RA, et al. Immunology. 2015 Oct;146(2):194-205. doi: 10.1111/imm.12507. Epub 2015 Sep 9. Immunology. 2015. PMID: 26190495 Free PMC article. Review. - A Study of Association Between Oral Lichen Planus and Immune Balance of Th1/Th2 Cells.
Wang Y, Zhou J, Fu S, Wang C, Zhou B. Wang Y, et al. Inflammation. 2015 Oct;38(5):1874-9. doi: 10.1007/s10753-015-0167-4. Inflammation. 2015. PMID: 25825144 - T helper 17 cells in the pathophysiology of acute and chronic kidney disease.
Basile DP, Ullah MM, Collet JA, Mehrotra P. Basile DP, et al. Kidney Res Clin Pract. 2021 Mar;40(1):12-28. doi: 10.23876/j.krcp.20.185. Epub 2021 Mar 23. Kidney Res Clin Pract. 2021. PMID: 33789382 Free PMC article. - T cell epitope mapping of JC polyoma virus-encoded proteome reveals reduced T cell responses in HLA-DRB1*04:01+ donors.
Jelcic I, Aly L, Binder TM, Jelcic I, Bofill-Mas S, Planas R, Demina V, Eiermann TH, Weber T, Girones R, Sospedra M, Martin R. Jelcic I, et al. J Virol. 2013 Mar;87(6):3393-408. doi: 10.1128/JVI.02803-12. Epub 2013 Jan 9. J Virol. 2013. PMID: 23302880 Free PMC article. - CsRNASET2 is an important component of Clonorchis sinensis responsible for eliciting Th2 immune response.
Xu Y, Lin J, Bian M, Chen W, Liang P, Wang X, Shang M, Qu H, Wu Z, Huang Y, Yu X. Xu Y, et al. Parasitol Res. 2015 Jun;114(6):2371-9. doi: 10.1007/s00436-015-4435-x. Epub 2015 Apr 2. Parasitol Res. 2015. PMID: 25828812
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials