New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system - PubMed (original) (raw)

Review

New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system

Susan F Volman et al. J Neurosci. 2013.

Abstract

The mesocorticolimbic system, consisting, at its core, of the ventral tegmental area, the nucleus accumbens, and medial prefrontal cortex, has historically been investigated primarily for its role in positively motivated behaviors and reinforcement learning, and its dysfunction in addiction, schizophrenia, depression, and other mood disorders. Recently, researchers have undertaken a more comprehensive analysis of this system, including its role in not only reward but also punishment, as well as in both positive and negative reinforcement. This focus has been facilitated by new anatomical, physiological, and behavioral approaches to delineate functional circuits underlying behaviors and to determine how this system flexibly encodes and responds to positive and negative states and events, beyond simple associative learning. This review is a summary of topics covered in a mini-symposium at the 2013 Society for Neuroscience annual meeting.

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References

    1. Aragona BJ, Day JJ, Roitman MF, Cleaveland NA, Wightman RM, Carelli RM. Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats. Eur J Neurosci. 2009;30:1889–1899. doi: 10.1111/j.1460-9568.2009.07027.x. - DOI - PMC - PubMed
    1. Balcita-Pedicino JJ, Omelchenko N, Bell R, Sesack SR. The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus. J Comp Neurol. 2011;519:1143–1164. doi: 10.1002/cne.22561. - DOI - PMC - PubMed
    1. Bals-Kubik R, Ableitner A, Herz A, Shippenberg TS. Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. J Pharmacol Exp Ther. 1993;264:489–495. - PubMed
    1. Bassareo V, De Luca MA, Di Chiara G. Differential expression of motivational stimulus properties by dopamine in nucleus accumbens shell versus core and prefrontal cortex. J Neurosci. 2002;22:4709–4719. - PMC - PubMed
    1. Bechara A, Harrington F, Nader K, van der Kooy D. Neurobiology of motivation-double dissociation of 2 motivational mechanisms mediating opiate reward in drug-naive versus drug-dependent animals. Behav Neurosci. 1992;106:798–807. doi: 10.1037/0735-7044.106.5.798. - DOI - PubMed

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