Long-term dynamics of adaptation in asexual populations - PubMed (original) (raw)
. 2013 Dec 13;342(6164):1364-7.
doi: 10.1126/science.1243357. Epub 2013 Nov 14.
Affiliations
- PMID: 24231808
- DOI: 10.1126/science.1243357
Long-term dynamics of adaptation in asexual populations
Michael J Wiser et al. Science. 2013.
Abstract
Experimental studies of evolution have increased greatly in number in recent years, stimulated by the growing power of genomic tools. However, organismal fitness remains the ultimate metric for interpreting these experiments, and the dynamics of fitness remain poorly understood over long time scales. Here, we examine fitness trajectories for 12 Escherichia coli populations during 50,000 generations. Mean fitness appears to increase without bound, consistent with a power law. We also derive this power-law relation theoretically by incorporating clonal interference and diminishing-returns epistasis into a dynamical model of changes in mean fitness over time.
Similar articles
- Sustained fitness gains and variability in fitness trajectories in the long-term evolution experiment with Escherichia coli.
Lenski RE, Wiser MJ, Ribeck N, Blount ZD, Nahum JR, Morris JJ, Zaman L, Turner CB, Wade BD, Maddamsetti R, Burmeister AR, Baird EJ, Bundy J, Grant NA, Card KJ, Rowles M, Weatherspoon K, Papoulis SE, Sullivan R, Clark C, Mulka JS, Hajela N. Lenski RE, et al. Proc Biol Sci. 2015 Dec 22;282(1821):20152292. doi: 10.1098/rspb.2015.2292. Proc Biol Sci. 2015. PMID: 26674951 Free PMC article. - Negative epistasis between beneficial mutations in an evolving bacterial population.
Khan AI, Dinh DM, Schneider D, Lenski RE, Cooper TF. Khan AI, et al. Science. 2011 Jun 3;332(6034):1193-6. doi: 10.1126/science.1203801. Science. 2011. PMID: 21636772 - The Nonstationary Dynamics of Fitness Distributions: Asexual Model with Epistasis and Standing Variation.
Martin G, Roques L. Martin G, et al. Genetics. 2016 Dec;204(4):1541-1558. doi: 10.1534/genetics.116.187385. Epub 2016 Oct 21. Genetics. 2016. PMID: 27770037 Free PMC article. - Genomic investigations of evolutionary dynamics and epistasis in microbial evolution experiments.
Jerison ER, Desai MM. Jerison ER, et al. Curr Opin Genet Dev. 2015 Dec;35:33-9. doi: 10.1016/j.gde.2015.08.008. Epub 2015 Sep 14. Curr Opin Genet Dev. 2015. PMID: 26370471 Free PMC article. Review. - Limits to adaptation in asexual populations.
de Visser JA, Rozen DE. de Visser JA, et al. J Evol Biol. 2005 Jul;18(4):779-88. doi: 10.1111/j.1420-9101.2005.00879.x. J Evol Biol. 2005. PMID: 16033549 Review.
Cited by
- Evolution of evolvability in rapidly adapting populations.
Ferrare JT, Good BH. Ferrare JT, et al. Nat Ecol Evol. 2024 Sep 11. doi: 10.1038/s41559-024-02527-0. Online ahead of print. Nat Ecol Evol. 2024. PMID: 39261599 - Genomic Pipeline for Analysis of Mutational Events in Bacteria.
Lemée P, Charron R, Bridier A. Lemée P, et al. Methods Mol Biol. 2025;2852:211-222. doi: 10.1007/978-1-0716-4100-2_15. Methods Mol Biol. 2025. PMID: 39235747 - Correlated responses to selection across diverse environments during experimental evolution of Tetrahymena thermophila.
Tarkington J, Zufall RA. Tarkington J, et al. Ecol Evol. 2024 Jul 23;14(7):e11395. doi: 10.1002/ece3.11395. eCollection 2024 Jul. Ecol Evol. 2024. PMID: 39045496 Free PMC article. - Effect of diet on the evolution of gut commensal bacteria.
Dapa T, Xavier KB. Dapa T, et al. Gut Microbes. 2024 Jan-Dec;16(1):2369337. doi: 10.1080/19490976.2024.2369337. Epub 2024 Jun 21. Gut Microbes. 2024. PMID: 38904092 Free PMC article. Review. - Convergent genetic adaptation of Escherichia coli in minimal media leads to pleiotropic divergence.
Venkataraman P, Nagendra P, Ahlawat N, Brajesh RG, Saini S. Venkataraman P, et al. Front Mol Biosci. 2024 Apr 10;11:1286824. doi: 10.3389/fmolb.2024.1286824. eCollection 2024. Front Mol Biosci. 2024. PMID: 38660375 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources