Medication regimen complexity and hospital readmission for an adverse drug event - PubMed (original) (raw)
Medication regimen complexity and hospital readmission for an adverse drug event
Megan N Willson et al. Ann Pharmacother. 2014 Jan.
Abstract
Background: Adverse drug events (ADEs) are costly, dangerous, and often preventable. Little is known about the link between medication regimen complexity and rehospitalization as a result of an ADE.
Objective: The objective of this study was to compare admission and discharge medication regimen complexity in 2 cohorts: patients readmitted for an ADE within 30 days and patients not readmitted for an ADE.
Methods: The study used a retrospective parallel-group case-control design. Participants from 4 urban acute care hospitals were included in the revisit cohort if they were rehospitalized within 30 days as a result of an adverse event coded as accidental poisoning. The no-revisit cohort was formed by randomly sampling patients with the same disease classification codes as the revisit group but without history of a readmission within 30 days. Complexity of medication regimens at the initial admission and discharge was quantified with the medication regimen complexity index (MRCI).
Results: The revisit group comprised 92 individuals and the no-revisit group, 228. The revisit group had a significantly higher MRCI score at admission and discharge than the no-revisit group (all P < .005). Receiver operating characteristic curves, used to determine a potential MRCI cutoff score for risk of an ADE, revealed MRCI scores of 8 or greater to optimally predict increased risk for readmission caused by an ADE.
Conclusions: Complex medication regimens at hospital admission are predictive of rehospitalizations for ADEs. This finding suggests that medication regimen complexity be considered as a target for interventions to decrease the risk for readmission.
Keywords: acute care; adverse drug event; hospital readmission; medication regimen complexity.
Similar articles
- Changes in medication regimen complexity and the risk for 90-day hospital readmission and/or emergency department visits in U.S. Veterans with heart failure.
Yam FK, Lew T, Eraly SA, Lin HW, Hirsch JD, Devor M. Yam FK, et al. Res Social Adm Pharm. 2016 Sep-Oct;12(5):713-21. doi: 10.1016/j.sapharm.2015.10.004. Epub 2015 Oct 27. Res Social Adm Pharm. 2016. PMID: 26621388 - Predicting potential postdischarge adverse drug events and 30-day unplanned hospital readmissions from medication regimen complexity.
Schoonover H, Corbett CF, Weeks DL, Willson MN, Setter SM. Schoonover H, et al. J Patient Saf. 2014 Dec;10(4):186-91. doi: 10.1097/PTS.0000000000000067. J Patient Saf. 2014. PMID: 25408236 - Discharge medication complexity and 30-day heart failure readmissions.
Colavecchia AC, Putney DR, Johnson ML, Aparasu RR. Colavecchia AC, et al. Res Social Adm Pharm. 2017 Jul-Aug;13(4):857-863. doi: 10.1016/j.sapharm.2016.10.002. Epub 2016 Oct 8. Res Social Adm Pharm. 2017. PMID: 27771308 - Medication Regimen Complexity in Long-Term Care Facilities and Adverse Drug Events-Related Hospitalizations.
Tam SHY, Hirsch JD, Watanabe JH. Tam SHY, et al. Consult Pharm. 2017 May 1;32(5):281-284. doi: 10.4140/TCP.n.2017.281. Consult Pharm. 2017. PMID: 28483008 Review. - Clinical Outcomes Associated with Medication Regimen Complexity in Older People: A Systematic Review.
Wimmer BC, Cross AJ, Jokanovic N, Wiese MD, George J, Johnell K, Diug B, Bell JS. Wimmer BC, et al. J Am Geriatr Soc. 2017 Apr;65(4):747-753. doi: 10.1111/jgs.14682. Epub 2016 Dec 19. J Am Geriatr Soc. 2017. PMID: 27991653 Review.
Cited by
- A Prospective Study of the Medication Regimen Complexity Index and Hospitalization Due to Adverse Drug Reactions Among People Living with HIV.
Poojar B, Kamath A, Rao SB, Ullal SD, Ramapuram J, Yadiyal MB, Shenoy AK. Poojar B, et al. Medicina (Kaunas). 2024 Oct 17;60(10):1705. doi: 10.3390/medicina60101705. Medicina (Kaunas). 2024. PMID: 39459492 Free PMC article. - Prevalence and predictors of polypharmacy and comorbidities among patients with chronic obstructive pulmonary disease: a cross-sectional retrospective study in a tertiary hospital in Saudi Arabia.
Alwafi H, Naser AY, Ashoor DS, Alsharif A, Aldhahir AM, Alghamdi SM, Alqarni AA, Alsaleh N, Samkari JA, Alsanosi SM, Alqahtani JS, Dairi MS, Hafiz W, Tashkandi M, Ashoor A, Badr OI. Alwafi H, et al. BMC Pulm Med. 2024 Sep 14;24(1):453. doi: 10.1186/s12890-024-03274-5. BMC Pulm Med. 2024. PMID: 39272014 Free PMC article. - Validation of an algorithm to prioritize patients for comprehensive medication management in primary care settings.
Bishop MA, Chang HY, Kitchen C, Pandya CJ, Brown D, Weiner JP, Shermock KM, Gudzune KA. Bishop MA, et al. Int J Clin Pharm. 2024 Oct;46(5):1232-1236. doi: 10.1007/s11096-024-01770-6. Epub 2024 Jul 23. Int J Clin Pharm. 2024. PMID: 39042353 - Pharmacist-led telehealth deprescribing for people living with dementia and polypharmacy in primary care: A pilot study.
Green AR, Quiles R, Daddato AE, Merrey J, Weffald L, Gleason K, Xue QL, Swarthout M, Feeser S, Boyd CM, Wolff JL, Blinka MD, Libby AM, Boxer RS. Green AR, et al. J Am Geriatr Soc. 2024 Jul;72(7):1973-1984. doi: 10.1111/jgs.18867. Epub 2024 Mar 15. J Am Geriatr Soc. 2024. PMID: 38488757 Clinical Trial. - Prediction of 30-day unplanned hospital readmission through survival analysis.
Pons-Suñer P, Arnal L, Signol F, Caballero Mateos MJ, Valdivieso Martínez B, Perez-Cortes JC. Pons-Suñer P, et al. Heliyon. 2023 Oct 16;9(10):e20942. doi: 10.1016/j.heliyon.2023.e20942. eCollection 2023 Oct. Heliyon. 2023. PMID: 37916107 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical