Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals - PubMed (original) (raw)
Randomized Controlled Trial
doi: 10.1016/j.clnu.2013.10.002. Epub 2013 Oct 10.
Affiliations
- PMID: 24268677
- DOI: 10.1016/j.clnu.2013.10.002
Randomized Controlled Trial
Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals
Nicholas P West et al. Clin Nutr. 2014 Aug.
Abstract
Background & aims: To examine the effect of supplementation with probiotics on respiratory and gastrointestinal illness in healthy active men and women.
Methods: A randomised double-blind placebo-controlled trial was conducted. Four hundred and sixty five participants (241 males; age 35 ± 12 y (mean ± SD) and 224 females; age 36 ± 12 y) were assigned to one of three groups: Group 1 - Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) 2.0 × 10(9)colony forming units per day, CFU per day, Group 2 - Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07 (NCFM & Bi-07) 5 × 10(9) CFU each per day) or Group 3 - placebo mixed in a drink.
Results: The risk of an upper respiratory illness episode was significantly lower in the Bl-04 group (hazard ratio 0.73; 95% confidence interval 0.55-0.95; P = 0.022) compared to placebo. There was no significant difference in illness risk between the NCFM & Bi-07 group (hazard ratio 0.81; 0.62-1.08; P = 0.15) and the placebo group. There was a 0.7 and 0.9 month delay in the median time to an illness episode in the Bl-04 and NCFM & Bi-07 groups respectively compared to placebo (placebo 2.5 months; Bl-04 3.2 months; NCFM & Bi-07 3.4 months). There were insufficient GI illness episodes for analysis. The NCFM & Bi-07 group but not the Bl-04 group undertook significantly more physical activity (8.5%; 6.7%-10%; P < 0.003) than the placebo group.
Conclusion: The probiotic Bl-04 appears to be a useful nutritional supplement in reducing the risk of URTI in healthy physically-active adults.
Trial registration: Australia New Zealand Clinical Trials Registry: Number ACTRN12611000130965.
Keywords: Bifidobacterium animalis Subsp. lactis Bi-07; Bifidobacterium animalis Subsp. lactis Bl-04; Healthy adults; Lactobacillus acidophilus NCFM; Probiotics; Respiratory illness.
Copyright © 2013. Published by Elsevier Ltd.
Comment in
- Questionnaire validation: Retrospective analysis of clinical data.
West NP, Pyne DB, Cripps AW; Probiotic Immune Research Consortium. West NP, et al. Clin Nutr. 2015 Dec;34(6):1283. doi: 10.1016/j.clnu.2015.07.020. Epub 2015 Aug 18. Clin Nutr. 2015. PMID: 26324015 No abstract available.
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