The carbohydrate-active enzymes database (CAZy) in 2013 - PubMed (original) (raw)

. 2014 Jan;42(Database issue):D490-5.

doi: 10.1093/nar/gkt1178. Epub 2013 Nov 21.

Affiliations

• PMID: 24270786
• PMCID: PMC3965031
• DOI: 10.1093/nar/gkt1178

The carbohydrate-active enzymes database (CAZy) in 2013

Vincent Lombard et al. Nucleic Acids Res. 2014 Jan.

Abstract

The Carbohydrate-Active Enzymes database (CAZy; http://www.cazy.org) provides online and continuously updated access to a sequence-based family classification linking the sequence to the specificity and 3D structure of the enzymes that assemble, modify and breakdown oligo- and polysaccharides. Functional and 3D structural information is added and curated on a regular basis based on the available literature. In addition to the use of the database by enzymologists seeking curated information on CAZymes, the dissemination of a stable nomenclature for these enzymes is probably a major contribution of CAZy. The past few years have seen the expansion of the CAZy classification scheme to new families, the development of subfamilies in several families and the power of CAZy for the analysis of genomes and metagenomes. This article outlines the changes that have occurred in CAZy during the past 5 years and presents our novel effort to display the resolution and the carbohydrate ligands in crystallographic complexes of CAZymes.

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Figures

Figure 1.

A view of the GH13 page showing the newly available 3D structural information (carbohydrate ligands and resolution) in the Structure tab.

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