Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria - PubMed (original) (raw)

Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria

Jean-Christophe Farges et al. Front Physiol. 2013.

No abstract available

Keywords: caries; dental pulp; dentine; healing; human tooth; inflammation; odontoblast; repair.

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Figures

Figure 1

Possible role of odontoblasts in the initiation of the dental pulp immune response to cariogenic bacteria. Oral bacteria that degrade dentine during carious lesions release pathogen-associated molecular patterns (PAMPs; brown dots) that may diffuse through the tubules to the odontoblast layer (brown arrows). Here, they are recognized by specific pathogen recognition receptors (pink cups) present at the odontoblast surface. Activation of specific intracellular pathways (dotted red lines) leads to the production of pro-inflammatory mediators including chemokines (blue squares) secreted at the opposite pole of the cell. These chemokines diffuse in the subodontoblast pulp area (blue arrow) and, upon binding to specific receptors (green boxes) attract antigen-presenting immature dendritic cells that ensure tissue immunosurveillance. These cells migrate to the odontoblast layer (gray arrows) to capture PAMPs arriving at the tubule pulpal end and develop the immune response and the associated inflammation.

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