Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies - PubMed (original) (raw)

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Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies

Guo-Chong Chen et al. J Am Heart Assoc. 2013.

Abstract

Background: Though vitamin C supplementation has shown no observed effects on stroke prevention in several clinical trials, uncertainty remains as to whether long-term, low-dose intake influences the development of stroke among general populations. Furthermore, the association between circulating vitamin C and the risk of stroke is also unclear. For further clarification of these issues, we conducted a meta-analysis of prospective studies.

Methods and results: PubMed and EMBASE databases were searched, and the bibliographies of the retrieved articles were also reviewed to identify eligible studies. Summary relative risk (RRs) with corresponding 95% confidence intervals (CIs) were computed with a random-effects model. The summary RR for the high-versus-low categories was 0.81 (95% CI: 0.74 to 0.90) for dietary vitamin C intake (11 studies), and 0.62 (95% CI: 0.49 to 0.79) for circulating vitamin C (6 studies). The summary RR for each 100 mg/day increment in dietary vitamin C was 0.83 (95% CI: 0.75 to 0.93) (10 studies), and for each 20 μmol/L increment in circulating vitamin C was 0.81 (95% CI: 0.75 to 0.88) (5 studies). Few studies reported results for vitamin C supplements (RR for high-versus-low intake=0.83, 95% CI: 0.62 to 1.10, 3 studies).

Conclusions: This meta-analysis suggests significant inverse relationships between dietary vitamin C intake, circulating vitamin C, and risk of stroke.

Keywords: antioxidants; diet; meta‐analysis; prevention; stroke.

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Figures

Figure 1.

Flow chart of study selection.

Figure 2.

Meta‐analysis of dietary vitamin C intake and risk of stroke. A, high vs low analysis; (B) dose‐response analysis. F indicates women; M, men; N.A., not available; RR, relative risk.

Figure 3.

Meta‐analysis of circulating vitamin C and risk of stroke. A, high vs low analysis; (B) dose‐response analysis. F indicates women; M, men; N.A., not available; RR, relative risk.

Figure 4.

Relative risk (solid line) with 95% confidence interval (long dashed lines) for the association between vitamin C intake (total or dietary intake) and risk of stroke in a restricted cubic spline random‐effects meta‐analysis. The lowest intake of 15.2 mg/day was used to estimate all relative risks.

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Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies - PubMed (original) (raw)