Influenza virus-induced encephalopathy in mice: interferon production and natural killer cell activity during acute infection - PubMed (original) (raw)

Influenza virus-induced encephalopathy in mice: interferon production and natural killer cell activity during acute infection

M A Wabuke-Bunoti et al. J Virol. 1986 Dec.

Abstract

Mice injected intracerebrally with infectious influenza virus (60 hemagglutinin units) developed lethargy, seizures, comas, and died 2 to 5 days postinfection. As early as 6 h after infection, the cerebrospinal fluid (CSF) in these animals was infiltrated with polymorphonuclear cells, mononuclear leukocytes, and large granular lymphocytes. Potent natural killer (NK) cell activity was observed for both CSF and spleen cell populations over the same period. This NK cell activity correlated with interferon (IFN) levels in the CSF and serum. Treatment of lethally infected mice with either anti-IFN alpha-IFN beta or anti-ganglio-n-tetraoglyceramide antiserum ameliorated the disease, reduced mortality, and effected changes in the relative proportions of inflammatory cell populations infiltrating the CSF. The possible significance of IFN and NK cell activity in the development of this influenza virus-induced encephalopathy is discussed.

PubMed Disclaimer

Cited by

Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy.
Kimura-Ohba S, Kitamura M, Tsukamoto Y, Kogaki S, Sakai S, Fushimi H, Matsuoka K, Takeuchi M, Itoh K, Ueda K, Kimura T. Kimura-Ohba S, et al. Acta Neuropathol. 2024 Apr 30;147(1):77. doi: 10.1007/s00401-024-02723-z. Acta Neuropathol. 2024. PMID: 38687393 Free PMC article.
Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys.
Hellmann I, Schmitz JE, Letvin NL. Hellmann I, et al. J Virol. 2012 Dec;86(23):13103-7. doi: 10.1128/JVI.00325-12. Epub 2012 Sep 26. J Virol. 2012. PMID: 23015705 Free PMC article.
Immune dysregulation in severe influenza.
Heltzer ML, Coffin SE, Maurer K, Bagashev A, Zhang Z, Orange JS, Sullivan KE. Heltzer ML, et al. J Leukoc Biol. 2009 Jun;85(6):1036-43. doi: 10.1189/jlb.1108710. J Leukoc Biol. 2009. PMID: 19276177 Free PMC article.
NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection.
Alter G, Altfeld M. Alter G, et al. J Intern Med. 2009 Jan;265(1):29-42. doi: 10.1111/j.1365-2796.2008.02045.x. J Intern Med. 2009. PMID: 19093958 Free PMC article. Review.
Biology of natural killer cells.
Trinchieri G. Trinchieri G. Adv Immunol. 1989;47:187-376. doi: 10.1016/s0065-2776(08)60664-1. Adv Immunol. 1989. PMID: 2683611 Free PMC article. Review.

References

1. Lancet. 1968 May 25;1(7552):1121-6 - PubMed
1. Br J Exp Pathol. 1960 Dec;41:586-92 - PubMed
1. Transplant Rev. 1974;19(0):89-120 - PubMed
1. Scand J Immunol. 1974;3(3):311-9 - PubMed
1. Lancet. 1976 Sep 18;2(7986):599-602 - PubMed

Influenza virus-induced encephalopathy in mice: interferon production and natural killer cell activity during acute infection - PubMed (original) (raw)