Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis - PubMed (original) (raw)
. 2013 Dec 6;342(6163):1243-6.
doi: 10.1126/science.1243364.
Affiliations
- PMID: 24311691
- DOI: 10.1126/science.1243364
Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis
Andrey A Kruglov et al. Science. 2013.
Abstract
Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However, mechanisms regulating IgA induction are not completely defined. We show that soluble lymphotoxin α (sLTα3) produced by RORγt(+) innate lymphoid cells (ILCs) controls T cell-dependent IgA induction in the lamina propria via regulation of T cell homing to the gut. By contrast, membrane-bound lymphotoxin β (LTα1β2) produced by RORγt(+) ILCs is critical for T cell-independent IgA induction in the lamina propria via control of dendritic cell functions. Ablation of LTα in RORγt(+) cells abrogated IgA production in the gut and altered microbiota composition. Thus, soluble and membrane-bound lymphotoxins produced by ILCs distinctly organize adaptive immune responses in the gut and control commensal microbiota composition.
Comment in
- Mucosal immunology: Innate control of IgA.
Bird L. Bird L. Nat Rev Immunol. 2014 Feb;14(2):66-7. doi: 10.1038/nri3613. Nat Rev Immunol. 2014. PMID: 24457481 No abstract available.
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