Mosquito transmission, growth phenotypes and the virulence of malaria parasites - PubMed (original) (raw)

Mosquito transmission, growth phenotypes and the virulence of malaria parasites

Laura C Pollitt et al. Malar J. 2013.

Abstract

Background: A series of elegant experiments was recently published which demonstrated that transmission of malaria parasites through mosquitoes elicited an attenuated growth phenotype, whereby infections grew more slowly and reached peak parasitaemia at least five-fold lower than parasites which had not been mosquito transmitted. To assess the implications of these results it is essential to understand whether the attenuated infection phenotype is a general phenomenon across parasites genotypes and conditions.

Methods: Using previously published data, the impact of mosquito transmission on parasite growth rates and virulence of six Plasmodium chabaudi lines was analysed.

Results: The effect of mosquito transmission varied among strains, but did not lead to pronounced or consistent reductions in parasite growth rate.

Conclusions: Mosquito-induced attenuated growth phenotype is sensitive to experimental conditions.

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Figures

Figure 1

Figure 1

Comparison of infection protocol between (A) Spence et al. [5]and (B) Mackinnon et al. [6]. Dashed boxes indicate the hosts from which data for the different types of infections (SBP, serially blood-passaged; MT, mosquito transmitted; recently MT) were generated.

Figure 2

Figure 2

The effect of mosquito transmission on infection dynamics and virulence depends on parasite line. Graphs show A) parasitaemia, B) parasite density, C) red blood cell density, D) change in weight from time of infection. Means of five to six replicate infections for serially blood-passaged parasites (red) and recently mosquito-transmitted lines (blue). Parasite line is shown at the top of each column. Bars show the standard error of the mean.

References

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