Regulation of voltage-dependent Ca2+ channels of neuronal cells by chronic changes in membrane potential - PubMed (original) (raw)
Regulation of voltage-dependent Ca2+ channels of neuronal cells by chronic changes in membrane potential
E M Delorme et al. Brain Res. 1986.
Free article
Abstract
The regulation of voltage-dependent Ca2+ channels by chronic changes in membrane potential was studied by measuring the binding of [3H]nitrendipine to membranes from PC12 pheochromocytoma cells. Depolarization of the cells by elevation of extracellular K+ caused up to a 45% loss of [3H]nitrendipine binding sites within 4 days without any change in Kd. Repolarization of the cells caused a return to control binding within 1-2 days, showing that either decreases or increases in membrane potential can cause reversible changes in [3H]nitrendipine binding sites.
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