Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes - PubMed (original) (raw)
. 2014 Jan 15;192(2):572-80.
doi: 10.4049/jimmunol.1302100. Epub 2013 Dec 11.
Hyun-Ja Ko, Ania Skowera, Gaurang Jhala, Tara Catterall, Kate L Graham, Robyn M Sutherland, Helen E Thomas, Andrew M Lew, Mark Peakman, Thomas W H Kay, Balasubramanian Krishnamurthy
Affiliations
- PMID: 24337380
- DOI: 10.4049/jimmunol.1302100
Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes
Jonathan Chee et al. J Immunol. 2014.
Abstract
CD8(+) T cells are critical in human type 1 diabetes and in the NOD mouse. In this study, we elucidated the natural history of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-specific CD8(+) T cells in NOD diabetes using MHC-tetramer technology. IGRP206-214-specific T cells in the peripheral lymphoid tissue increased with age, and their numbers correlated with insulitis progression. IGRP206-214-specific T cells in the peripheral lymphoid tissue expressed markers of chronic Ag stimulation, and their numbers were stable after diagnosis of diabetes, consistent with their memory phenotype. IGRP206-214-specific T cells in NOD mice expand, acquire the phenotype of effector-memory T cells in the islets, and emigrate to the peripheral lymphoid tissue. Our observations suggest that enumeration of effector-memory T cells of multiple autoantigen specificities in the periphery of type 1 diabetic subjects could be a reliable reporter for progression of islet pathology.
Comment in
- Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE.
Garyu JW, Uduman M, Stewart A, Rui J, Deng S, Shenson J, Staron MM, Kaech SM, Kleinstein SH, Herold KC. Garyu JW, et al. J Biol Chem. 2016 May 20;291(21):11230-40. doi: 10.1074/jbc.M115.713362. Epub 2016 Mar 18. J Biol Chem. 2016. PMID: 26994137 Free PMC article.
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