Long noncoding RNA in prostate, bladder, and kidney cancer - PubMed (original) (raw)
Review
. 2014 Jun;65(6):1140-51.
doi: 10.1016/j.eururo.2013.12.003. Epub 2013 Dec 14.
Affiliations
- PMID: 24373479
- DOI: 10.1016/j.eururo.2013.12.003
Review
Long noncoding RNA in prostate, bladder, and kidney cancer
Elena S Martens-Uzunova et al. Eur Urol. 2014 Jun.
Abstract
Context: Genomic regions without protein-coding potential give rise to millions of protein-noncoding RNA transcripts (noncoding RNA) that participate in virtually all cellular processes. Research over the last 10 yr has accumulated evidence that long noncoding RNAs (lncRNAs) are often altered in human urologic cancers.
Objective: To review current progress in the biology and implication of lncRNAs associated with prostate, bladder, and kidney cancer.
Evidence acquisition: The PubMed database was searched for articles in the English language with combinations of the Medical Subject Headings terms long non coding RNA, long noncoding RNA, long untranslated RNA, cancer, neoplasms, prostate, bladder, and kidney.
Evidence synthesis: We summarise existing knowledge on the systematics, biology, and function of lncRNAs, particularly these involved in prostate, kidney, and bladder cancer. We also discuss the possible utilisation of lncRNAs as novel biomarkers and potential therapeutic targets in urologic malignancies and portray the major challenges and future perspectives of ongoing lncRNA research.
Conclusions: LncRNAs are important regulators of gene expression interacting with the major pathways of cell growth, proliferation, differentiation, and survival. Alterations in the function of lncRNAs promote tumour formation, progression, and metastasis of prostate, bladder, and kidney cancer. LncRNAs can be used as noninvasive tumour markers in urologic malignancies. Increased knowledge of the molecular mechanisms by which lncRNAs perform their function in the normal and malignant cell will lead to a better understanding of tumour biology and could provide novel therapeutic targets for the treatment of urologic cancers.
Patient summary: In this paper we reviewed current knowledge of long noncoding RNAs (lncRNAs) for the detection and treatment of urologic cancers. We conclude that lncRNAs can be used as novel biomarkers in prostate, kidney, or bladder cancer. LncRNAs hold promise as future therapeutic targets, but more research is needed to gain a better understanding of their biologic function.
Keywords: Beckwith-Wiedemann syndrome; Bladder cancer; Kidney cancer; Long noncoding RNA; Prostate cancer; Renal cell carcinoma; Urothelial carcinoma; Wilms tumour; lncRNA.
Copyright © 2013 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Comment in
- Long noncoding RNA: "LNCs" to cancer.
Sültmann H, Diederichs S. Sültmann H, et al. Eur Urol. 2014 Jun;65(6):1152-3. doi: 10.1016/j.eururo.2014.01.032. Epub 2014 Jan 31. Eur Urol. 2014. PMID: 24508069 No abstract available.
Similar articles
- Clinical prospects of long noncoding RNAs as novel biomarkers and therapeutic targets in prostate cancer.
Mouraviev V, Lee B, Patel V, Albala D, Johansen TE, Partin A, Ross A, Perera RJ. Mouraviev V, et al. Prostate Cancer Prostatic Dis. 2016 Mar;19(1):14-20. doi: 10.1038/pcan.2015.48. Epub 2015 Oct 27. Prostate Cancer Prostatic Dis. 2016. PMID: 26503110 Review. - Urinary long noncoding RNAs in nonmuscle-invasive bladder cancer: new architects in cancer prognostic biomarkers.
Terracciano D, Ferro M, Terreri S, Lucarelli G, D'Elia C, Musi G, de Cobelli O, Mirone V, Cimmino A. Terracciano D, et al. Transl Res. 2017 Jun;184:108-117. doi: 10.1016/j.trsl.2017.03.005. Epub 2017 Apr 7. Transl Res. 2017. PMID: 28438520 Review. - The evolution of long noncoding RNA acceptance in prostate cancer initiation, progression, and its clinical utility in disease management.
Ramnarine VR, Kobelev M, Gibb EA, Nouri M, Lin D, Wang Y, Buttyan R, Davicioni E, Zoubeidi A, Collins CC. Ramnarine VR, et al. Eur Urol. 2019 Nov;76(5):546-559. doi: 10.1016/j.eururo.2019.07.040. Epub 2019 Aug 22. Eur Urol. 2019. PMID: 31445843 Review. - Identification of differentially expressed long noncoding RNAs in bladder cancer.
Peter S, Borkowska E, Drayton RM, Rakhit CP, Noon A, Chen W, Catto JW. Peter S, et al. Clin Cancer Res. 2014 Oct 15;20(20):5311-21. doi: 10.1158/1078-0432.CCR-14-0706. Epub 2014 Aug 27. Clin Cancer Res. 2014. PMID: 25165097 - Comprehensive Characterization of Common and Cancer-Specific Differently Expressed lncRNAs in Urologic Cancers.
Yan YJ, Zhang L, Zhou JJ, Chen ZJ, Liao YX, Zeng JM, Shen H. Yan YJ, et al. Comput Math Methods Med. 2021 Jul 9;2021:5515218. doi: 10.1155/2021/5515218. eCollection 2021. Comput Math Methods Med. 2021. PMID: 34335862 Free PMC article.
Cited by
- Long Non-Coding RNA GAS5 Suppresses Tumor Progression and Enhances the Radiosensitivity of Prostate Cancer Through the miR-320a/RAB21 Axis.
Ma X, Wang Z, Ren H, Bao X, Zhang Y, Wang B, Ruan D. Ma X, et al. Cancer Manag Res. 2020 Sep 22;12:8833-8845. doi: 10.2147/CMAR.S244123. eCollection 2020. Cancer Manag Res. 2020. PMID: 33061579 Free PMC article. - Differentially expressed circulating LncRNAs and mRNA identified by microarray analysis in obese patients.
Sun J, Ruan Y, Wang M, Chen R, Yu N, Sun L, Liu T, Chen H. Sun J, et al. Sci Rep. 2016 Oct 21;6:35421. doi: 10.1038/srep35421. Sci Rep. 2016. PMID: 27767123 Free PMC article. - Novel long non-coding RNAs are specific diagnostic and prognostic markers for prostate cancer.
Böttcher R, Hoogland AM, Dits N, Verhoef EI, Kweldam C, Waranecki P, Bangma CH, van Leenders GJ, Jenster G. Böttcher R, et al. Oncotarget. 2015 Feb 28;6(6):4036-50. doi: 10.18632/oncotarget.2879. Oncotarget. 2015. PMID: 25686826 Free PMC article. - An autophagy-related long non-coding RNA prognostic signature accurately predicts survival outcomes in bladder urothelial carcinoma patients.
Sun Z, Jing C, Xiao C, Li T. Sun Z, et al. Aging (Albany NY). 2020 Aug 29;12(15):15624-15637. doi: 10.18632/aging.103718. Aging (Albany NY). 2020. PMID: 32805727 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical