The chemistry of self-splicing RNA and RNA enzymes - PubMed (original) (raw)

The chemistry of self-splicing RNA and RNA enzymes

T R Cech. Science. 1987.

Abstract

Proteins are not the only catalysts of cellular reactions; there is a growing list of RNA molecules that catalyze RNA cleavage and joining reactions. The chemical mechanisms of RNA-catalyzed reactions are discussed with emphasis on the self-splicing ribosomal RNA precursor of Tetrahymena and the enzymatic activities of its intervening sequence RNA. Wherever appropriate, catalysis by RNA is compared to catalysis by protein enzymes.

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