Burden of illness, quality of life, and healthcare utilization among patients with herpes zoster in South Korea: a prospective clinical-epidemiological study - PubMed (original) (raw)
Observational Study
doi: 10.1016/j.ijid.2013.11.018. Epub 2014 Jan 8.
Jeongdeuk Lee 2, Muhyung Lee 3, Won Suk Choi 4, Jung Hyun Choi 5, Mi Suk Lee 6, Mahdi Hashemi 7, Emmanouil Rampakakis 8, Kosuke Kawai 9, Ron White 10, Camilo Acosta 10, John S Sampalis 8, Hee Jin Cheong 11
Affiliations
- PMID: 24412314
- DOI: 10.1016/j.ijid.2013.11.018
Free article
Observational Study
Burden of illness, quality of life, and healthcare utilization among patients with herpes zoster in South Korea: a prospective clinical-epidemiological study
Haejun Song et al. Int J Infect Dis. 2014 Mar.
Free article
Abstract
Objectives: To assess the herpes zoster (HZ) disease burden, including the severity and duration of HZ-associated pain, its impact on quality of life (QoL), and healthcare resource utilization (HCRU) in a South Korean clinical setting.
Methods: Patients aged ≥50 years were followed prospectively for ≤6 months. Based on the duration of their episode at enrollment, cases were classified as incident (<7 days) or prevalent (≥7 days). HZ pain and discomfort were measured with the HZ Severity of Illness (HZ-SOI) severity-by-duration composite score.
Results: One hundred fifty-one patients (69.5% prevalent cases) were enrolled. Prodrome pain was experienced by 68.2% of patients, of whom 95.1% experienced moderate-to-severe pain; post-herpetic neuralgia was experienced by 38.4%. Prevalent disease, higher acute pain, and older age were significant predictors of greater HZ-SOI, while use of antivirals was associated with decreased HZ-SOI. HZ-associated pain was associated with reduced QoL and affected all daily living activities (particularly mood, life enjoyment, general activities, and sleep), resulting in significant HCRU, including primary care doctor, specialist, or physiotherapist consultations, hospitalizations, and emergency department visits.
Conclusion: Severe morbidity, impaired QoL, and significant HCRU are associated with HZ in South Korea, especially in older patients, supporting the need for early intervention and preventive strategies to reduce the HZ-associated disease burden.
Keywords: Burden of illness; Herpes zoster; Observational; Pain; Quality of life; South Korea.
Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
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