Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene - PubMed (original) (raw)
Comparative Study
Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene
R T Boggs et al. Cell. 1987.
Abstract
The transformer (tra) gene regulates female somatic sexual differentiation and has no known function in males. It gives rise to two sizes of RNA, one non-sex-specific and one female-specific. These two RNAs are shown to be present throughout the life cycle, and related by the use of alternative first intron splice acceptor sites. The non-sex-specific RNA has a 73 base first intron, while that in the female-specific RNA is 248 bases. The non-sex-specific RNA has no long open reading frame, while the female-specific RNA has a single long open reading frame beginning at the first AUG. Substitution of a heat shock promoter for the tra promoter still leads to female-specific differentiation of otherwise tra-females. We suggest a mechanism by which Sex-lethal controls itself and tra.
Similar articles
- Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript.
Inoue K, Hoshijima K, Sakamoto H, Shimura Y. Inoue K, et al. Nature. 1990 Mar 29;344(6265):461-3. doi: 10.1038/344461a0. Nature. 1990. PMID: 1690860 - Interspecific comparison of the transformer gene of Drosophila reveals an unusually high degree of evolutionary divergence.
O'Neil MT, Belote JM. O'Neil MT, et al. Genetics. 1992 May;131(1):113-28. doi: 10.1093/genetics/131.1.113. Genetics. 1992. PMID: 1592233 Free PMC article. - Ectopic expression of the female transformer gene product leads to female differentiation of chromosomally male Drosophila.
McKeown M, Belote JM, Boggs RT. McKeown M, et al. Cell. 1988 Jun 17;53(6):887-95. doi: 10.1016/s0092-8674(88)90369-8. Cell. 1988. PMID: 2454747 - Molecular genetic aspects of sex determination in Drosophila melanogaster.
Baker BS, Burtis K, Goralski T, Mattox W, Nagoshi R. Baker BS, et al. Genome. 1989;31(2):638-45. doi: 10.1139/g89-117. Genome. 1989. PMID: 2517260 Review. - Genetic control of sex determination in Drosophila.
Steinmann-Zwicky M, Amrein H, Nöthiger R. Steinmann-Zwicky M, et al. Adv Genet. 1990;27:189-237. doi: 10.1016/s0065-2660(08)60026-7. Adv Genet. 1990. PMID: 2112300 Review. No abstract available.
Cited by
- Soma-germline communication drives sex maintenance in the Drosophila testis.
Zhang R, Shi P, Xu S, Ming Z, Liu Z, He Y, Dai J, Matunis E, Xu J, Ma Q. Zhang R, et al. Natl Sci Rev. 2024 Jun 22;11(8):nwae215. doi: 10.1093/nsr/nwae215. eCollection 2024 Aug. Natl Sci Rev. 2024. PMID: 39183747 Free PMC article. - Cellular sex throughout the organism underlies somatic sexual differentiation.
Hérault C, Pihl T, Hudry B. Hérault C, et al. Nat Commun. 2024 Aug 13;15(1):6925. doi: 10.1038/s41467-024-51228-6. Nat Commun. 2024. PMID: 39138201 Free PMC article. - The sex of organ geometry.
Blackie L, Gaspar P, Mosleh S, Lushchak O, Kong L, Jin Y, Zielinska AP, Cao B, Mineo A, Silva B, Ameku T, Lim SE, Mao Y, Prieto-Godino L, Schoborg T, Varela M, Mahadevan L, Miguel-Aliaga I. Blackie L, et al. Nature. 2024 Jun;630(8016):392-400. doi: 10.1038/s41586-024-07463-4. Epub 2024 May 29. Nature. 2024. PMID: 38811741 Free PMC article. - A Fluorescent Sex-Sorting Technique for Insects with the Demonstration in Drosophila melanogaster.
Liu J, Rayes D, Akbari OS. Liu J, et al. GEN Biotechnol. 2024 Feb 1;3(1):35-44. doi: 10.1089/genbio.2023.0041. Epub 2024 Feb 15. GEN Biotechnol. 2024. PMID: 38415050 - Evolution of sex-determination in dioecious plants: From active Y to X/A balance?
Kazama Y, Kobayashi T, Filatov DA. Kazama Y, et al. Bioessays. 2023 Nov;45(11):e2300111. doi: 10.1002/bies.202300111. Epub 2023 Sep 11. Bioessays. 2023. PMID: 37694687 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases