Action of 3-methylquercetin on poliovirus RNA replication - PubMed (original) (raw)

Action of 3-methylquercetin on poliovirus RNA replication

J L Castrillo et al. J Virol. 1987 Oct.

Abstract

3-Methylquercetin is a natural flavone that powerfully blocks poliovirus replication. This compound inhibits selectively poliovirus RNA synthesis both in infected cells and in cell-free systems. Poliovirus double-stranded RNA (replicative forms) is still made in the presence of this inhibitor, whereas the synthesis of single-stranded RNA and the formation of replicative intermediates are drastically blocked.

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