Y-box binding protein 1--a prognostic marker and target in tumour therapy - PubMed (original) (raw)

Review

. 2014 Jan-Feb;93(1-2):61-70.

doi: 10.1016/j.ejcb.2013.11.007. Epub 2013 Dec 27.

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Review

Y-box binding protein 1--a prognostic marker and target in tumour therapy

Corinna Kosnopfel et al. Eur J Cell Biol. 2014 Jan-Feb.

Abstract

Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular processes including both transcriptional and translational regulation of target gene expression. Significantly increased YB-1 levels have been reported in a number of human malignancies and shown to be associated with poor prognosis and disease recurrence. Indeed, YB-1 can act as a versatile oncoprotein playing an important role in tumour cell proliferation and progression. Consequently, YB-1 not only proves to be a good prognostic tumour marker, but also may be a promising emerging molecular target for the development of new therapeutical strategies. In this review, we discuss both the role of YB-1 in cancer and specifically in malignant melanoma as well as possible translations into the clinics derived thereof.

Keywords: Angiogenesis; Chemoresistance; DNA repair; Genomic instability; Migration/invasion; Oncogene; Proliferation; Survival; Transcription factor; Translational regulation.

Copyright © 2014 Elsevier GmbH. All rights reserved.

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