Epigenome-wide association studies without the need for cell-type composition - PubMed (original) (raw)
doi: 10.1038/nmeth.2815. Epub 2014 Jan 26.
Affiliations
- PMID: 24464286
- DOI: 10.1038/nmeth.2815
Epigenome-wide association studies without the need for cell-type composition
James Zou et al. Nat Methods. 2014 Mar.
Abstract
In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition--information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from http://www.microsoft.com/science/.
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