MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer - PubMed (original) (raw)
doi: 10.1016/j.humimm.2014.01.006. Epub 2014 Jan 24.
Lanxin Chen 2, Lingting Zou 2, Panpan Yang 3, Ruirong Wu 3, Yong Mao 3, Huan Zhou 4, Rui Li 5, Kaicai Wang 6, Weipeng Wang 7, Dong Hua 8, Xueguang Zhang 5
Affiliations
- PMID: 24468585
- DOI: 10.1016/j.humimm.2014.01.006
MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer
Jianjie Zhu et al. Hum Immunol. 2014 Apr.
Abstract
Co-inhibitor B7-H1 expresses in various cancers and contributes to cancer immune evasion by inhibiting T cell activation and proliferation, yet the regulatory mechanisms for B7-H1 over-expression in cancers remain largely unknown. Here, the expression of B7-H1 and PTEN proteins were firstly detected by using immunohistochemistry method. B7-H1 immunoreactivities were found in 54.5% (55/101) of the colorectal cancer tissues with no expression in the normal tissues, and the PTEN protein immunoreactivities were observed in 51.5% (52/101) of the colorectal cancer tissues and 72.3% (73/101) of the normal tissues. Statistical analysis results indicated that the B7-H1 expression was negatively correlated to the PTEN expression in colorectal cancer (p=0.001). Then the expressions of microRNAs (miRNAs) in six pairs of colorectal cancer and normal tissues were determined by miRNA array, and 30 up-regulated miRNAs were found in the colorectal cancer tissues. Finally, the impact of these up-regulated miRNAs on PTEN expression was tested by using dual-luciferase reporter assay system, from which the results indicated that miR-20b, -21, and -130b were involved in suppression of PTEN expression. These findings suggest that miR-20b, -21, and -130b, up-regulated in colorectal cancer, through inhibiting the expression of PTEN, result in B7-H1 over-expression in colorectal cancer.
Copyright © 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Similar articles
- MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells.
Yu T, Cao R, Li S, Fu M, Ren L, Chen W, Zhu H, Zhan Q, Shi R. Yu T, et al. BMC Cancer. 2015 Jan 31;15:29. doi: 10.1186/s12885-015-1031-5. BMC Cancer. 2015. PMID: 25637514 Free PMC article. - Colorectal cancer cell-derived exosomal miRNA-372-5p induces immune escape from colorectal cancer via PTEN/AKT/NF-κB/PD-L1 pathway.
Wu Y, Xiao Y, Ding Y, Ran R, Wei K, Tao S, Mao H, Wang J, Pang S, Shi J, Zhu C, Wan W, Yang Q, Chen C. Wu Y, et al. Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113261. doi: 10.1016/j.intimp.2024.113261. Epub 2024 Sep 30. Int Immunopharmacol. 2024. PMID: 39353381 - MicroRNA-152 regulates immune response via targeting B7-H1 in gastric carcinoma.
Wang Y, Wang D, Xie G, Yin Y, Zhao E, Tao K, Li R. Wang Y, et al. Oncotarget. 2017 Apr 25;8(17):28125-28134. doi: 10.18632/oncotarget.15924. Oncotarget. 2017. PMID: 28427226 Free PMC article. - PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer.
Song M, Chen D, Lu B, Wang C, Zhang J, Huang L, Wang X, Timmons CL, Hu J, Liu B, Wu X, Wang L, Wang J, Liu H. Song M, et al. PLoS One. 2013 Jun 13;8(6):e65821. doi: 10.1371/journal.pone.0065821. Print 2013. PLoS One. 2013. PMID: 23785454 Free PMC article. - How MicroRNAs Command the Battle against Cancer.
Wu HH, Leng S, Sergi C, Leng R. Wu HH, et al. Int J Mol Sci. 2024 May 28;25(11):5865. doi: 10.3390/ijms25115865. Int J Mol Sci. 2024. PMID: 38892054 Free PMC article. Review.
Cited by
- MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications.
Strubberg AM, Madison BB. Strubberg AM, et al. Dis Model Mech. 2017 Mar 1;10(3):197-214. doi: 10.1242/dmm.027441. Dis Model Mech. 2017. PMID: 28250048 Free PMC article. Review. - The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint.
Wang Q, Lin W, Tang X, Li S, Guo L, Lin Y, Kwok HF. Wang Q, et al. Int J Mol Sci. 2017 Nov 27;18(12):2540. doi: 10.3390/ijms18122540. Int J Mol Sci. 2017. PMID: 29186904 Free PMC article. Review. - Indirect Down-regulation of Tumor-suppressive let-7 Family MicroRNAs by LMO1 in Neuroblastoma.
Saeki N, Saito A, Sugaya Y, Amemiya M, Sasaki H. Saeki N, et al. Cancer Genomics Proteomics. 2018 Sep-Oct;15(5):413-420. doi: 10.21873/cgp.20100. Cancer Genomics Proteomics. 2018. PMID: 30194082 Free PMC article. - The dual role of microRNA (miR)-20b in cancers: Friend or foe?
İlhan A, Golestani S, Shafagh SG, Asadi F, Daneshdoust D, Al-Naqeeb BZT, Nemati MM, Khalatbari F, Yaseri AF. İlhan A, et al. Cell Commun Signal. 2023 Jan 30;21(1):26. doi: 10.1186/s12964-022-01019-7. Cell Commun Signal. 2023. PMID: 36717861 Free PMC article. Review. - Current insight into the regulation of PD-L1 in cancer.
Liu Z, Yu X, Xu L, Li Y, Zeng C. Liu Z, et al. Exp Hematol Oncol. 2022 Jul 30;11(1):44. doi: 10.1186/s40164-022-00297-8. Exp Hematol Oncol. 2022. PMID: 35907881 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials