Analysis of an outbreak of hemorrhagic fever with renal syndrome in college students in Xi'an, China - PubMed (original) (raw)

Analysis of an outbreak of hemorrhagic fever with renal syndrome in college students in Xi'an, China

Chaofeng Ma et al. Viruses. 2014.

Abstract

The aim of the present study was to analyze an outbreak of hemorrhagic fever with renal syndrome (HFRS), caused by a Hantavirus, in college students in the northern urban area of Xi'an in 2012. The outbreak affected six students and included two deaths. The epidemiological survey revealed that both of the deceased cases were misdiagnosed initially, and treatment was delayed. Furthermore, a higher rodent population density and lower HFRS vaccine coverage were observed in the affected area, which indicates a possible role in the outbreak. Rattus norvegicus (Rn) and Mus musculus (Mm) were the predominant host populations in the area. Genotyping revealed that all HVs from patients and rodents were Hantaan virus (HTNV). Sequence analysis of the S segments revealed that the HTNVs reported in this study had high similarity with strains reported in 2011 and 1985, but these viruses diverged from a strain isolated in 1984 and the HTNV prototype strain 76-118. Detection of anti-HV IgG and amplification of the S segment of HTNV from a non-natural HTNV reservoir indicates that further investigations by increased rodent trapping are necessary.

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Figures

Figure 1

Figure 1

Map of locations of colleges.

Figure 2

Figure 2

Phylogenetic tree of S segments from related hantaviruses. Mega 5 was used to construct the phylogenetic trees by using the neighbor-joining (NJ) and the maximum likelihood (ML) methods with 1,000 bootstrap replicates. S segment of Seoulvirus (SEOV) was used as an out-group. (●AY273791 SEOV 80–39). ▲The sequences reported in this study.

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