Scientific evaluation of the acute toxicity and 13-week subchronic toxicity of Rheum emodi rhizome extracts in Sprague Dawley rats - PubMed (original) (raw)

Scientific evaluation of the acute toxicity and 13-week subchronic toxicity of Rheum emodi rhizome extracts in Sprague Dawley rats

Ben-Gui Ye et al. Food Chem Toxicol. 2014 Apr.

Abstract

Rheum emodi has been used as an edible and medicinal plant in Tibet and Kashmir for a long period of time, while safety evaluation of this plant has not yet been investigated. In this study, acute and subchronic oral toxicity studies of aqueous extract of R. emodi (AERE) rhizome were conducted in SD rats. Animals were treated with a single dose of 1000, 2000, 4000 or 10,000 mg/kg of AERE in the acute toxicity. In subchronic oral toxicity, animals were randomly divided into four groups (10 rats/sex/group) and received doses of 0, 1000, 2000, and 4000 mg/kg/d of AERE for 90 days. Daily clinical observations, weekly measurement of body weight and food consumption were conducted. Blood and urine were collected on days 91 to measure changes. At necropsy, selected organs were weighed and recorded, and histological examination was performed. During the subchronic oral toxicity study, no mortality, obvious treatment-related clinical signs and urinalysis parameters were observed. Differences in weight gain, food consumption, hematology, biochemistry, relative organ weight and histopathology examinations between the treated group and the control group were not considered treatment-related. Our results indicated that the no-observed-adverse-effect level (NOAEL) for AERE was 4000 mg/kg/d in both genders.

Keywords: Acute oral toxicity; Rheum emodi; Sprague–Dawley rats; Subchronic toxicity.

PubMed Disclaimer

Cited by

Therapeutic and pharmacological efficacy of plant-derived bioactive compounds in targeting breast cancer.
Saini H, Basu P, Nesari T, Huddar VG, Ray K, Srivastava A, Gupta S, Mehrotra R, Tripathi R. Saini H, et al. Am J Transl Res. 2024 May 15;16(5):1499-1520. doi: 10.62347/NUZN4999. eCollection 2024. Am J Transl Res. 2024. PMID: 38883353 Free PMC article. Review.
Polysaccharides extracted from Rheum tanguticum ameliorate radiation-induced enteritis via activation of Nrf2/HO-1.
Zhang T, Shi L, Li Y, Mu W, Zhang H, Li Y, Wang X, Zhao W, Qi Y, Liu L. Zhang T, et al. J Radiat Res. 2021 Jan 1;62(1):46-57. doi: 10.1093/jrr/rraa093. J Radiat Res. 2021. PMID: 33140083 Free PMC article.
Shenhuang granule in the treatment of severe coronavirus disease 2019 (COVID-19): study protocol for an open-label randomized controlled clinical trial.
Fang B, Zhang W, Wu X, Huang T, Li H, Zheng Y, Che J, Sun S, Jiang C, Zhou S, Feng J. Fang B, et al. Trials. 2020 Jun 24;21(1):568. doi: 10.1186/s13063-020-04498-6. Trials. 2020. PMID: 32580752 Free PMC article.
Assessment of ramie leaf (Boehmeria nivea L. gaud) as an animal feed supplement in P.R. China.
Mu L, Cai M, Wang Z, Liu J, Liu T, Wanapat M, Huang B. Mu L, et al. Trop Anim Health Prod. 2020 Jan;52(1):115-121. doi: 10.1007/s11250-019-01997-w. Epub 2019 Jul 4. Trop Anim Health Prod. 2020. PMID: 31273580
Acute and Subchronic Toxicity Studies of Aqueous Extract of Desmodium adscendens (Sw) DC.
Quaye O, Cramer P, Ofosuhene M, Okine LKN, Nyarko AK. Quaye O, et al. J Evid Based Complementary Altern Med. 2017 Oct;22(4):753-759. doi: 10.1177/2156587217736587. Epub 2017 Nov 7. J Evid Based Complementary Altern Med. 2017. PMID: 29228815 Free PMC article.

Scientific evaluation of the acute toxicity and 13-week subchronic toxicity of Rheum emodi rhizome extracts in Sprague Dawley rats - PubMed (original) (raw)