Modulation of T-type calcium channels by bioactive lipids - PubMed (original) (raw)
Review
. 2014 Apr;466(4):689-700.
doi: 10.1007/s00424-014-1467-5. Epub 2014 Feb 16.
Affiliations
- PMID: 24531745
- DOI: 10.1007/s00424-014-1467-5
Review
Modulation of T-type calcium channels by bioactive lipids
Jean Chemin et al. Pflugers Arch. 2014 Apr.
Abstract
T-type calcium channels (T-channels/CaV3) have unique biophysical properties allowing a calcium influx at resting membrane potential of most cells. T-channels are ubiquitously expressed in many tissues and contribute to low-threshold spikes and burst firing in central neurons as well as to pacemaker activities in cardiac cells. They also emerged as potential targets to treat cancer and hypertension. Regulation of these channels appears complex, and several studies have indicated that CaV3.1, CaV3.2, and CaV3.3 currents are directly inhibited by multiple endogenous lipids independently of membrane receptors or intracellular pathways. These bioactive lipids include arachidonic acid and ω3 poly-unsaturated fatty acids; the endocannabinoid anandamide and other N-acylethanolamides; the lipoamino-acids and lipo-neurotransmitters; the P450 epoxygenase metabolite 5,6-epoxyeicosatrienoic acid; as well as similar molecules with 18-22 carbons in the alkyl chain. In this review, we summarize evidence for direct effects of these signaling molecules, the molecular mechanisms underlying the current inhibition, and the involved chemical features. The impact of this modulation in physiology and pathophysiology is discussed with a special emphasis on pain aspects and vasodilation. Overall, these data clearly indicate that T-current inhibition is an important mechanism by which bioactive lipids mediate their physiological functions.
Similar articles
- Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels.
Chemin J, Nargeot J, Lory P. Chemin J, et al. J Biol Chem. 2007 Jan 26;282(4):2314-23. doi: 10.1074/jbc.M610033200. Epub 2006 Nov 22. J Biol Chem. 2007. PMID: 17121818 - Cross-modulation and molecular interaction at the Cav3.3 protein between the endogenous lipids and the T-type calcium channel antagonist TTA-A2.
Cazade M, Nuss CE, Bidaud I, Renger JJ, Uebele VN, Lory P, Chemin J. Cazade M, et al. Mol Pharmacol. 2014 Feb;85(2):218-25. doi: 10.1124/mol.113.089581. Epub 2013 Nov 8. Mol Pharmacol. 2014. PMID: 24214826 - T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.
Barbara G, Alloui A, Nargeot J, Lory P, Eschalier A, Bourinet E, Chemin J. Barbara G, et al. J Neurosci. 2009 Oct 21;29(42):13106-14. doi: 10.1523/JNEUROSCI.2919-09.2009. J Neurosci. 2009. PMID: 19846698 Free PMC article. - Modulation of neuronal T-type calcium channels.
Lambert RC, Bessaih T, Leresche N. Lambert RC, et al. CNS Neurol Disord Drug Targets. 2006 Dec;5(6):611-27. doi: 10.2174/187152706779025544. CNS Neurol Disord Drug Targets. 2006. PMID: 17168746 Review. - Molecular physiology of low-voltage-activated t-type calcium channels.
Perez-Reyes E. Perez-Reyes E. Physiol Rev. 2003 Jan;83(1):117-61. doi: 10.1152/physrev.00018.2002. Physiol Rev. 2003. PMID: 12506128 Review.
Cited by
- Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years.
Maccarrone M, Di Marzo V, Gertsch J, Grether U, Howlett AC, Hua T, Makriyannis A, Piomelli D, Ueda N, van der Stelt M. Maccarrone M, et al. Pharmacol Rev. 2023 Sep;75(5):885-958. doi: 10.1124/pharmrev.122.000600. Epub 2023 May 10. Pharmacol Rev. 2023. PMID: 37164640 Free PMC article. Review. - Conceptual DFT, QTAIM, and Molecular Docking Approaches to Characterize the T-Type Calcium Channel Blocker Anandamide.
Rangel-Galván M, Castro ME, Perez-Aguilar JM, Caballero NA, Melendez FJ. Rangel-Galván M, et al. Front Chem. 2022 Jul 14;10:920661. doi: 10.3389/fchem.2022.920661. eCollection 2022. Front Chem. 2022. PMID: 35910732 Free PMC article. - Receptor-Dependent and Independent Regulation of Voltage-Gated Ca2+ Channels and Ca2+-Permeable Channels by Endocannabinoids in the Brain.
Boczek T, Zylinska L. Boczek T, et al. Int J Mol Sci. 2021 Jul 29;22(15):8168. doi: 10.3390/ijms22158168. Int J Mol Sci. 2021. PMID: 34360934 Free PMC article. Review. - Neuronal Cav3 channelopathies: recent progress and perspectives.
Lory P, Nicole S, Monteil A. Lory P, et al. Pflugers Arch. 2020 Jul;472(7):831-844. doi: 10.1007/s00424-020-02429-7. Epub 2020 Jul 7. Pflugers Arch. 2020. PMID: 32638069 Free PMC article. Review. - Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats.
Shen FY, Lim BG, Wen W, Zhang Y, Cao B, Si YG, Ma LQ, Deng M, Kim YI, Kim YB, Wang YW. Shen FY, et al. Neurosci Bull. 2020 May;36(5):519-529. doi: 10.1007/s12264-019-00461-x. Epub 2020 Jan 17. Neurosci Bull. 2020. PMID: 31953800 Free PMC article.
References
- J Lipid Res. 2003 Dec;44(12):2221-33 - PubMed
- Circ Res. 2005 Oct 28;97(9):908-15 - PubMed
- J Gen Physiol. 2004 Sep;124(3):225-38 - PubMed
- Bioorg Med Chem Lett. 2011 Mar 15;21(6):1692-6 - PubMed
- Br J Pharmacol. 2011 Jun;163(3):484-95 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources