Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy - PubMed (original) (raw)

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

J L Urban et al. Cell. 1988.

Abstract

Experimental allergic encephalomyelitis (EAE) is a paralytic autoimmune disease induced in susceptible animals by active immunization with myelin basic protein (MBP) or by passive transfer of MBP-specific T helper (TH) lymphocytes. We have analyzed the T cell receptor genes of 33 clonally distinct TH cells specific for a nonapeptide of MBP inducing EAE in B10.PL (H-2u) mice. All 33 TH cells used two alpha variable gene segments (V alpha 2.3, 61%; V alpha 4.2, 39%), the same alpha joining gene segment (J alpha 39), and two V beta and J beta gene segments (V beta 8.2-J beta 2.6, 79%; V beta 13-J beta 2.2, 21%). The anti-V beta 8 monoclonal antibody F23.1 was found to block completely recognition of the nonapeptide by V beta 8 TH cells in vitro and to reduce significantly the susceptibility of B10.PL mice to peptide-induced EAE.

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[No authors listed] [No authors listed] NIH Guide Grants Contracts (Bethesda). 1995 Jul 28;24(27):3. NIH Guide Grants Contracts (Bethesda). 1995. PMID: 7612298 Free PMC article. No abstract available.

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Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy - PubMed (original) (raw)