Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals - PubMed (original) (raw)
Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals
Sedigheh Asgary et al. ARYA Atheroscler. 2013 Nov.
Abstract
Background: Pomegranate juice (PJ) is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial investigated the acute effects of PJ consumption on blood pressure and markers of endothelial function.
Methods: In this single-arm study, thirteen hypertensive men aged 39-68 years were recruited. Included subjects were assigned to natural PJ (150 ml/day) following a 12 hour fast. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and flow-mediated dilation (FMD), along with serum concentrations of C-reactive protein (CRP), intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin and interleukin-6 (IL-6) were measured at baseline and 4-6 hours after PJ consumption.
Results: Comparison of pre- vs. post-trial values revealed a significant reduction in both SBP (7%; P = 0.013) and DBP (6%; P < 0.010). However, changes in FMD (20%) as well as circulating levels of CRP, ICAM-1, VCAM-1, E-selectin, and IL-6 did not reach statistical significance (P = 0.172).
Conclusion: PJ has promising acute hypotensive properties. Consumption of PJ could be considered in the context of both dietary and pharmacological interventions for hypertension.
Keywords: Cardiovascular Disease; Endothelium-Dependent Dilation; Hypertension; Inflammation; Punica Granatum L..
Similar articles
- Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects.
Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian-Kopaei M. Asgary S, et al. Phytother Res. 2014 Feb;28(2):193-9. doi: 10.1002/ptr.4977. Epub 2013 Mar 21. Phytother Res. 2014. PMID: 23519910 - Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: A single-blind randomized clinical trial.
Sohrab G, Roshan H, Ebrahimof S, Nikpayam O, Sotoudeh G, Siasi F. Sohrab G, et al. Clin Nutr ESPEN. 2019 Feb;29:30-35. doi: 10.1016/j.clnesp.2018.11.013. Epub 2018 Dec 20. Clin Nutr ESPEN. 2019. PMID: 30661697 Clinical Trial. - Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome.
Kelishadi R, Gidding SS, Hashemi M, Hashemipour M, Zakerameli A, Poursafa P. Kelishadi R, et al. J Res Med Sci. 2011 Mar;16(3):245-53. J Res Med Sci. 2011. PMID: 22091240 Free PMC article. - Impact of pomegranate juice on blood pressure: A systematic review and meta-analysis.
Ghaemi F, Emadzadeh M, Atkin SL, Jamialahmadi T, Zengin G, Sahebkar A. Ghaemi F, et al. Phytother Res. 2023 Oct;37(10):4429-4441. doi: 10.1002/ptr.7952. Epub 2023 Jul 17. Phytother Res. 2023. PMID: 37461211 Review. - Effects of supplementation with pomegranate juice on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials.
Sahebkar A, Gurban C, Serban A, Andrica F, Serban MC. Sahebkar A, et al. Phytomedicine. 2016 Oct 15;23(11):1095-102. doi: 10.1016/j.phymed.2015.12.008. Epub 2015 Dec 30. Phytomedicine. 2016. PMID: 26922037 Review.
Cited by
- Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences.
Nasri H, Bahmani M, Shahinfard N, Moradi Nafchi A, Saberianpour S, Rafieian Kopaei M. Nasri H, et al. Jundishapur J Microbiol. 2015 Nov 21;8(11):e25580. doi: 10.5812/jjm.25580. eCollection 2015 Nov. Jundishapur J Microbiol. 2015. PMID: 26862380 Free PMC article. Review. - New concepts in nutraceuticals as alternative for pharmaceuticals.
Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M. Nasri H, et al. Int J Prev Med. 2014 Dec;5(12):1487-99. Int J Prev Med. 2014. PMID: 25709784 Free PMC article. Review. - Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials.
Eghbali S, Askari SF, Avan R, Sahebkar A. Eghbali S, et al. J Nutr Metab. 2021 Nov 16;2021:5297162. doi: 10.1155/2021/5297162. eCollection 2021. J Nutr Metab. 2021. PMID: 34796029 Free PMC article. Review. - Effects of Pomegranate Seed Oil on Metabolic State of Patients with Type 2 Diabetes Mellitus.
Faghihimani Z, Mirmiran P, Sohrab G, Iraj B, Faghihimani E. Faghihimani Z, et al. Int J Prev Med. 2016 Nov 29;7:124. doi: 10.4103/2008-7802.194883. eCollection 2016. Int J Prev Med. 2016. PMID: 27994825 Free PMC article. - Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.
Fekete M, Szarvas Z, Fazekas-Pongor V, Feher A, Csipo T, Forrai J, Dosa N, Peterfi A, Lehoczki A, Tarantini S, Varga JT. Fekete M, et al. Nutrients. 2022 Dec 22;15(1):47. doi: 10.3390/nu15010047. Nutrients. 2022. PMID: 36615705 Free PMC article. Review.
References
- Kochanek KD, Xu J, Murphy SL, Minino AM, Kung HC. Deaths: Final Data for 2009. National Vital Statistics Reports. 2011;60(3):1–110. - PubMed
- Whitworth JA. 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens. 2003;21(11):1983–92. - PubMed
- Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217–23. - PubMed
- Hajjar I, Kotchen JM, Kotchen TA. Hypertension: trends in prevalence, incidence, and control. Annu Rev Public Health. 2006;27:465–90. - PubMed
- Fazizi F, Esmaillzadeh A, Mirmiran FP. Obesity and cardiovascular disease risk factors in Tehran adults: a population-based study. East Mediterr Health J. 2004;10(6):887–97. - PubMed
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous