Brazilian nut consumption by healthy volunteers improves inflammatory parameters - PubMed (original) (raw)
Randomized Controlled Trial
doi: 10.1016/j.nut.2013.10.005. Epub 2013 Oct 14.
Carlos Dalton D A Vilanova 2, Luiz Gustavo B Reetz 3, Marta M M F Duarte 4, Iria Luiza G Farias 3, Daiane F Meinerz 2, Douglas O C Mariano 2, Raquel G Vendrusculo 5, Aline A Boligon 6, Cristiane L Dalla Corte 2, Roger Wagner 5, Margareth L Athayde 6, João Batista T da Rocha 7
Affiliations
- PMID: 24607303
- DOI: 10.1016/j.nut.2013.10.005
Randomized Controlled Trial
Brazilian nut consumption by healthy volunteers improves inflammatory parameters
Elisângela Colpo et al. Nutrition. 2014 Apr.
Abstract
Objective: The aim of this study was to investigate the effect of a single dose of Brazil nuts on the inflammatory markers of healthy individuals.
Method: A randomized crossover study was conducted with 10 healthy individuals (mean age 24.7 ± 3.4 y). Each individual was tested four times regarding intake of different portions of Brazil nuts: 0, 5, 20 and 50 g. At each testing period, peripheral blood was collected before and at 1, 3, 6, 9, 24, and 48 h after intake of nuts, as well as at 5 and 30 d after intake of various Brazil nut portions. Blood samples were tested for high-sensitivity to C-reactive protein, interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, aspartate and alanine aminotransferases, albumin, total protein, alkaline phosphatase, gamma-glutamyltransferase, urea, and creatinine.
Results: Consumption of nuts did not affect biochemical parameters for liver and kidney function, indicating absence of hepatic and renal toxicity. A single intake of Brazil nuts (20 or 50 g) caused a significant decrease in serum IL-1, IL-6, TNF-α, and IFN-γ levels (P < 0.05), whereas serum levels of IL-10 were significantly increased (P < 0.05).
Conclusion: The results indicate a long-term decrease in inflammatory markers after a single intake of large portions of Brazil nuts in healthy volunteers. Therefore, the long-term effect of regular Brazil nut consumption on inflammatory markers should be better investigated.
Keywords: C-reactive protein; Human; Interleukin; Nutrition; Oxidative stress; Selenium; Unsaturated fatty acids.
Copyright © 2014 Elsevier Inc. All rights reserved.
Similar articles
- Brazil nut (Bertholletia excelsa, H.B.K.) improves oxidative stress and inflammation biomarkers in hemodialysis patients.
Stockler-Pinto MB, Mafra D, Moraes C, Lobo J, Boaventura GT, Farage NE, Silva WS, Cozzolino SF, Malm O. Stockler-Pinto MB, et al. Biol Trace Elem Res. 2014 Apr;158(1):105-12. doi: 10.1007/s12011-014-9904-z. Epub 2014 Feb 8. Biol Trace Elem Res. 2014. PMID: 24504745 Clinical Trial. - A single consumption of high amounts of the Brazil nuts improves lipid profile of healthy volunteers.
Colpo E, Vilanova CD, Brenner Reetz LG, Medeiros Frescura Duarte MM, Farias IL, Irineu Muller E, Muller AL, Moraes Flores EM, Wagner R, da Rocha JB. Colpo E, et al. J Nutr Metab. 2013;2013:653185. doi: 10.1155/2013/653185. Epub 2013 Jun 11. J Nutr Metab. 2013. PMID: 23840948 Free PMC article. - Effect of Brazil nut supplementation on plasma levels of selenium in hemodialysis patients: 12 months of follow-up.
Stockler-Pinto MB, Lobo J, Moraes C, Leal VO, Farage NE, Rocha AV, Boaventura GT, Cozzolino SM, Malm O, Mafra D. Stockler-Pinto MB, et al. J Ren Nutr. 2012 Jul;22(4):434-9. doi: 10.1053/j.jrn.2011.08.011. Epub 2012 Jan 3. J Ren Nutr. 2012. PMID: 22217537 - The effect of nuts on inflammation.
Salas-Salvadó J, Casas-Agustench P, Murphy MM, López-Uriarte P, Bulló M. Salas-Salvadó J, et al. Asia Pac J Clin Nutr. 2008;17 Suppl 1:333-6. Asia Pac J Clin Nutr. 2008. PMID: 18296371 Review. - Brazil nuts: Nutritional composition, health benefits and safety aspects.
Cardoso BR, Duarte GBS, Reis BZ, Cozzolino SMF. Cardoso BR, et al. Food Res Int. 2017 Oct;100(Pt 2):9-18. doi: 10.1016/j.foodres.2017.08.036. Epub 2017 Aug 14. Food Res Int. 2017. PMID: 28888463 Review.
Cited by
- Effects of Cashew Nuts (Anacardium occidentale L.) and Cashew Nut Oil on Intestinal Permeability and Inflammatory Markers during an Energy-Restricted 8-Week Intervention: A Randomized Controlled Trial (Brazilian Nuts Study).
Meneguelli TS, Wendling AL, Kravchychyn ACP, Rocha DMUP, Dionísio AP, Bressan J, Martino HSD, Tako E, Hermsdorff HHM. Meneguelli TS, et al. Foods. 2024 Sep 14;13(18):2917. doi: 10.3390/foods13182917. Foods. 2024. PMID: 39335845 Free PMC article. - A U.S. Pharmacopeia (USP) overview of Pan American botanicals used in dietary supplements and herbal medicines.
Upton R, Agudelo I, Cabrera Y, Caceres A, Calderón A, Calzada F, Camacho R, da Costa F, Dobrecky C, Enciso R, Escobar M, Fakhary M, Fletcher E, Gao Q, Lock O, Mata R, Parada M, Perera W, Pombo LM, Reich E, Sanchez E, Simirgiotis MJ, Sood C, Amiguet VT, Villar M, Ghelman R, Schveitzer MC, Portella CFS, Wolffenbüttel A, Ruppelt B, Frickmann FS, Gavillan-Suarez J, Allen K, Alvarado LD, Sarma N, Marles R, Monagas M, Navarro-Hoyos M. Upton R, et al. Front Pharmacol. 2024 Aug 30;15:1426210. doi: 10.3389/fphar.2024.1426210. eCollection 2024. Front Pharmacol. 2024. PMID: 39281273 Free PMC article. Review. - The Cardioprotective Properties of Selected Nuts: Their Functional Ingredients and Molecular Mechanisms.
Olas B. Olas B. Foods. 2024 Jan 11;13(2):242. doi: 10.3390/foods13020242. Foods. 2024. PMID: 38254543 Free PMC article. Review. - Functional Fruit Trees from the Atlantic and Amazon Forests: Selection of Potential Chestnut Trees Rich in Antioxidants, Nutrients, and Fatty Acids.
Palacio de Araujo C, Medeiros Simões I, Lins Monteiro Rosa T, de Mello T, Bravim Canal G, Ferreira A, Bestete de Oliveira JP, Romais Schmildt E, Lopes JC, da Silva de Souza T, Otoni WC, Pinheiro PF, Moreira Novaes FJ, Gonçalves FG, Santos ARD, Sobreira Alexandre R. Palacio de Araujo C, et al. Foods. 2023 Dec 9;12(24):4422. doi: 10.3390/foods12244422. Foods. 2023. PMID: 38137226 Free PMC article. - Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers.
Parilli-Moser I, Domínguez-López I, Vallverdú-Queralt A, Hurtado-Barroso S, Lamuela-Raventós RM. Parilli-Moser I, et al. Antioxidants (Basel). 2023 Mar 11;12(3):698. doi: 10.3390/antiox12030698. Antioxidants (Basel). 2023. PMID: 36978946 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials