Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development - PubMed (original) (raw)
Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development
K Ito et al. Proc Natl Acad Sci U S A. 1989 Jan.
Abstract
We have analyzed the structural diversity of the murine gamma delta T-cell receptor (TCR) heterodimer expressed on CD4- CD8- thymocyte populations and on TCR gamma delta-expressing hybridomas derived from thymocytes of fetal, newborn, and adult mice. We found that CD4- CD8- thymocytes derived from mice of different pre- and postnatal age preferentially express a gamma delta TCR encoded by different subsets of gamma and delta gene segments. This age-dependent differential expression of gamma delta TCR on thymocytes seems to be accomplished in part by a specific control of rearranged gamma genes operating at the level of transcription and/or RNA stability. We discuss the implications of these findings with respect to the recognition roles of the gamma delta TCR.
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References
- Cell. 1985 Feb;40(2):259-69 - PubMed
- Cell. 1986 Jun 6;45(5):733-42 - PubMed
- Nature. 1986 Jul 10-16;322(6075):145-9 - PubMed
- Nature. 1986 Jul 10-16;322(6075):179-81 - PubMed
- Science. 1986 Dec 12;234(4782):1401-5 - PubMed
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