Human monocyte activation induced by an anti-CD14 monoclonal antibody - PubMed (original) (raw)
Human monocyte activation induced by an anti-CD14 monoclonal antibody
C Schütt et al. Immunol Lett. 1988 Dec.
Abstract
An anti-CD14 mAb RoMo-1 rapidly induces in human monocytes a transient oxidative burst activity as detected by chemiluminescence assay. Pretreatment of these cells with the mAb markedly suppresses the monocyte chemiluminescence response to opsonized zymosan. In addition, the antibody induces a significant increase of IL-1 production and secretion by mononuclear cells, comparable to a similar effect of rIFN-gamma or LPS. Electron microscopy demonstrates internalization of the CD14 molecules after interaction with the mAb in a characteristic receptor-like manner.
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