Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review - PubMed (original) (raw)
Review
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review
Joana Bicker et al. Eur J Pharm Biopharm. 2014 Aug.
Abstract
During the research and development of new drugs directed at the central nervous system, there is a considerable attrition rate caused by their hampered access to the brain by the blood-brain barrier. Throughout the years, several in vitro models have been developed in an attempt to mimic critical functionalities of the blood-brain barrier and reliably predict the permeability of drug candidates. However, the current challenge lies in developing a model that retains fundamental blood-brain barrier characteristics and simultaneously remains compatible with the high throughput demands of pharmaceutical industries. This review firstly describes the roles of all elements of the neurovascular unit and their influence on drug brain penetration. In vitro models, including non-cell based and cell-based models, and in vivo models are herein presented, with a particular emphasis on their methodological aspects. Lastly, their contribution to the improvement of brain drug delivery strategies and drug transport across the blood-brain barrier is also discussed.
Keywords: 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP (PubChem CID: 91636); Adenosine 3',5'-cyclic monophosphate (PubChem CID: 6076); Brain uptake; CNS drugs; Cell culture; Dodecane (PubChem CID: 8182); Drug discovery and development; Fluorescein isothiocyanate (PubChem CID: 18730); Hydrocortisone (PubChem CID: 5754); In vitro; In vivo; Inulin(PubChem CID: 18772499); Neurovascular unit; PAMPA; Permeability screening; Propranolol (PubChem CID: 4946); Sodium fluorescein (PubChem CID: 9885981); Sucrose (PubChem CID: 5988); Targeted drug delivery; Vinblastine (PubChem CID: 13342).
Copyright © 2014 Elsevier B.V. All rights reserved.
Similar articles
- In vitro porcine blood-brain barrier model for permeability studies: pCEL-X software pKa(FLUX) method for aqueous boundary layer correction and detailed data analysis.
Yusof SR, Avdeef A, Abbott NJ. Yusof SR, et al. Eur J Pharm Sci. 2014 Dec 18;65:98-111. doi: 10.1016/j.ejps.2014.09.009. Epub 2014 Sep 18. Eur J Pharm Sci. 2014. PMID: 25239510 - A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.
Bicker J, Alves G, Fortuna A, Soares-da-Silva P, Falcão A. Bicker J, et al. Int J Pharm. 2016 Mar 30;501(1-2):102-11. doi: 10.1016/j.ijpharm.2016.01.074. Epub 2016 Feb 1. Int J Pharm. 2016. PMID: 26836708 - Prediction of blood-brain barrier permeation of α-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis.
Vucicevic J, Nikolic K, Dobričić V, Agbaba D. Vucicevic J, et al. Eur J Pharm Sci. 2015 Feb 20;68:94-105. doi: 10.1016/j.ejps.2014.12.014. Epub 2014 Dec 24. Eur J Pharm Sci. 2015. PMID: 25542610 - [The blood-brain barrier and drug delivery in the central nervous system].
Loch-Neckel G, Koepp J. Loch-Neckel G, et al. Rev Neurol. 2010 Aug;51(3):165-74. Rev Neurol. 2010. PMID: 20645267 Review. Spanish.
Cited by
- Alterations in Pericyte Subpopulations Are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer.
Lyle LT, Lockman PR, Adkins CE, Mohammad AS, Sechrest E, Hua E, Palmieri D, Liewehr DJ, Steinberg SM, Kloc W, Izycka-Swieszewska E, Duchnowska R, Nayyar N, Brastianos PK, Steeg PS, Gril B. Lyle LT, et al. Clin Cancer Res. 2016 Nov 1;22(21):5287-5299. doi: 10.1158/1078-0432.CCR-15-1836. Epub 2016 May 31. Clin Cancer Res. 2016. PMID: 27245829 Free PMC article. - Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity.
Bowman P, Flanagan SE, Hattersley AT. Bowman P, et al. J Diabetes Res. 2018 Nov 27;2018:3061620. doi: 10.1155/2018/3061620. eCollection 2018. J Diabetes Res. 2018. PMID: 30599002 Free PMC article. Review. - A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress.
Molins Gutiérrez G, Martorell J, Salazar-Martin AG, Balcells M. Molins Gutiérrez G, et al. Methods Mol Biol. 2022;2492:175-190. doi: 10.1007/978-1-0716-2289-6_10. Methods Mol Biol. 2022. PMID: 35733045 - A MALDI-TOF-based Method for Studying the Transport of BBB Shuttles-Enhancing Sensitivity and Versatility of Cell-Based In Vitro Transport Models.
Arranz-Gibert P, Guixer B, Prades R, Ciudad S, Giralt E, Teixidó M. Arranz-Gibert P, et al. Sci Rep. 2019 Mar 19;9(1):4875. doi: 10.1038/s41598-019-40973-0. Sci Rep. 2019. PMID: 30890722 Free PMC article. - A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort.
Tien AC, Li J, Bao X, Derogatis A, Kim S, Mehta S, Sanai N. Tien AC, et al. Clin Cancer Res. 2019 Oct 1;25(19):5777-5786. doi: 10.1158/1078-0432.CCR-19-0133. Epub 2019 Jul 8. Clin Cancer Res. 2019. PMID: 31285369 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical